Version 5.4
Homo sapiens Gene: PRKCD
Summary
InnateDB Gene IDBG-40082.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRKCD
Gene Name protein kinase C, delta
Synonyms CVID9; MAY1; nPKC-delta; PKCD
Species Homo sapiens
Ensembl Gene ENSG00000163932
Encoded Proteins
IDBP-40084
protein kinase C, delta
IDBP-240984
protein kinase C, delta
IDBP-480980
protein kinase C, delta
IDBP-484179
protein kinase C, delta
IDBP-484665
protein kinase C, delta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 19150425
Following TNF stimulation, PRKCD phosphorylates TRAF2 leading to CHUK (IKK alpha) and IKBKB (IKK beta) recruitment to the TNF receptor
PMID 22265677
PRKCD is an essential signalling kinase in C-type lectin receptor-mediated innate immunity and host protection. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
PMID 22265677
[Mus musculus] Prkcd is an essential signalling kinase in C-type lectin receptor-mediated innate immunity and host protection.
PMID 23326354
[Mus musculus] Suppression of Prkcd expression inhibited nitric oxide production in activated macrophages.
Entrez Gene
Summary Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:53156009-53192717
Strand Forward strand
Band p21.1
Transcripts
ENST00000330452 ENSP00000331602
ENST00000394729 ENSP00000378217
ENST00000478843 ENSP00000419726
ENST00000477794
ENST00000487897 ENSP00000418106
ENST00000464818 ENSP00000419629
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 123 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 123 [view]
Protein-Protein 122 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004697 protein kinase C activity
GO:0004699 calcium-independent protein kinase C activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008047 enzyme activator activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019899 enzyme binding
GO:0043560 insulin receptor substrate binding
GO:0046872 metal ion binding
Biological Process
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0007049 cell cycle
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007596 blood coagulation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010467 gene expression
GO:0010469 regulation of receptor activity
GO:0016064 immunoglobulin mediated immune response
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0018107 peptidyl-threonine phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0023021 termination of signal transduction
GO:0030168 platelet activation
GO:0030837 negative regulation of actin filament polymerization
GO:0032091 negative regulation of protein binding
GO:0032613 interleukin-10 production
GO:0032615 interleukin-12 production
GO:0032930 positive regulation of superoxide anion generation
GO:0034351 negative regulation of glial cell apoptotic process
GO:0035307 positive regulation of protein dephosphorylation
GO:0035556 intracellular signal transduction
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042100 B cell proliferation
GO:0042119 neutrophil activation
GO:0042742 defense response to bacterium
GO:0043407 negative regulation of MAP kinase activity
GO:0045087 innate immune response (InnateDB)
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050728 negative regulation of inflammatory response
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0050821 protein stabilization
GO:0051490 negative regulation of filopodium assembly
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0090331 negative regulation of platelet aggregation
GO:0090398 cellular senescence
GO:1900163 positive regulation of phospholipid scramblase activity
GO:2000304 positive regulation of ceramide biosynthetic process
GO:2000753 positive regulation of glucosylceramide catabolic process
GO:2000755 positive regulation of sphingomyelin catabolic process
GO:2001022 positive regulation of response to DNA damage stimulus
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0016363 nuclear matrix
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021948
View Gene Order
ENSBTAG00000008719
Not yet available
Pathways
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_4
EGFR1 pathway
NetPath_8
Wnt pathway
NetPath_9
TNFalpha pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_16
IL4 pathway
NetPath_17
IL5 pathway
NetPath_18
IL6 pathway
NetPath_22
Leptin pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_9000
Calmodulin induced events pathway
REACT_9053
CaM pathway pathway
REACT_111064
DAG and IP3 signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_160158
Role of phospholipids in phagocytosis pathway
REACT_25078
Interferon gamma signaling pathway
REACT_2202
Effects of PIP2 hydrolysis pathway
REACT_12079
PLC-gamma1 signalling pathway
REACT_12478
EGFR interacts with phospholipase C-gamma pathway
REACT_9417
Signaling by EGFR pathway
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_19333
G alpha (z) signalling events pathway
REACT_15426
PLC beta mediated events pathway
REACT_15295
Opioid Signalling pathway
REACT_115720
PLCG1 events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21310
Phospholipase C-mediated cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_25218
HuR stabilizes mRNA pathway
REACT_107
Apoptotic cleavage of cellular proteins pathway
REACT_995
Apoptotic execution phase pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_12529
Signaling by VEGF pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_578
Apoptosis pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_25229
Interferon Signaling pathway
REACT_15526
G-protein mediated events pathway
REACT_6900
Immune System pathway
REACT_228024
VEGFR2 mediated cell proliferation pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_24994
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_15307
Ca-dependent events pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_604
Hemostasis pathway
KEGG
hsa04912
GnRH signaling pathway pathway
hsa04664
Fc epsilon RI signaling pathway pathway
hsa04530
Tight junction pathway
hsa04930
Type II diabetes mellitus pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04062
Chemokine signaling pathway pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
FGF signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
INOH website
NGF signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
pi3kplctrkpathway
Trk receptor signaling mediated by PI3K and PLC-gamma
syndecan_2_pathway
Syndecan-2-mediated signaling events
ceramide_pathway
Ceramide signaling pathway
alphasynuclein_pathway
Alpha-synuclein signaling
mapktrkpathway
Trk receptor signaling mediated by the MAPK pathway
lysophospholipid_pathway
LPA receptor mediated events
thrombin_par1_pathway
PAR1-mediated thrombin signaling events
erbb1_downstream_pathway
ErbB1 downstream signaling
igf1_pathway
IGF1 pathway
p53regulationpathway
p53 pathway
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
syndecan_4_pathway
Syndecan-4-mediated signaling events
hedgehog_glipathway
Hedgehog signaling events mediated by Gli proteins
tap63pathway
Validated transcriptional targets of TAp63 isoforms
pdgfrbpathway
PDGFR-beta signaling pathway
il6_7pathway
IL6-mediated signaling events
ifngpathway
IFN-gamma pathway
Cross-References
SwissProt Q05655
TrEMBL A0A024R328 B4DFV1 C9J9P1 C9JZU8 C9K0E3
UniProt Splice Variant
Entrez Gene 5580
UniGene Hs.155342
RefSeq NM_006254 NM_212539 XM_006713257 XM_006713258
HUGO HGNC:9399
OMIM 176977
CCDS CCDS2870
HPRD
IMGT
EMBL AC097015 AK294272 AK313216 BC043350 CH471055 D10495 DQ516383 L07860 L07861 Z22521
GenPept AAA03175 AAA03176 AAH43350 ABF68960 BAA01381 BAG36031 BAG57562 CAA80249 EAW65279 EAW65280
RNA Seq Atlas 5580

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca