Version 5.4
Homo sapiens Gene: MYL6
Summary
InnateDB Gene IDBG-40095.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYL6
Gene Name myosin, light chain 6, alkali, smooth muscle and non-muscle
Synonyms ESMLC; LC17; LC17-GI; LC17-NM; LC17A; LC17B; MLC-3; MLC1SM; MLC3NM; MLC3SM
Species Homo sapiens
Ensembl Gene ENSG00000092841
Encoded Proteins
IDBP-40097
myosin, light chain 6, alkali, smooth muscle and non-muscle
IDBP-40099
myosin, light chain 6, alkali, smooth muscle and non-muscle
IDBP-600908
myosin, light chain 6, alkali, smooth muscle and non-muscle
IDBP-588088
myosin, light chain 6, alkali, smooth muscle and non-muscle
IDBP-585632
myosin, light chain 6, alkali, smooth muscle and non-muscle
IDBP-596118
myosin, light chain 6, alkali, smooth muscle and non-muscle
IDBP-583800
myosin, light chain 6, alkali, smooth muscle and non-muscle
IDBP-594867
myosin, light chain 6, alkali, smooth muscle and non-muscle
IDBP-597233
myosin, light chain 6, alkali, smooth muscle and non-muscle
IDBP-587376
myosin, light chain 6, alkali, smooth muscle and non-muscle
IDBP-597378
myosin, light chain 6, alkali, smooth muscle and non-muscle
IDBP-592131
myosin, light chain 6, alkali, smooth muscle and non-muscle
IDBP-594897
myosin, light chain 6, alkali, smooth muscle and non-muscle
IDBP-593701
myosin, light chain 6, alkali, smooth muscle and non-muscle
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been described and two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:56158161-56163496
Strand Forward strand
Band q13.2
Transcripts
ENST00000348108 ENSP00000301540
ENST00000293422 ENSP00000293422
ENST00000550697 ENSP00000446955
ENST00000548580 ENSP00000446640
ENST00000550184
ENST00000552297
ENST00000549017 ENSP00000449086
ENST00000547703
ENST00000549566 ENSP00000446709
ENST00000536128 ENSP00000441750
ENST00000547649 ENSP00000446714
ENST00000548725
ENST00000547408 ENSP00000446721
ENST00000551589 ENSP00000446687
ENST00000550639
ENST00000546630
ENST00000549392 ENSP00000450116
ENST00000548400 ENSP00000448859
ENST00000548293 ENSP00000448101
ENST00000546845 ENSP00000448457
ENST00000551954
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 43 [view]
Protein-Protein 43 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003774 motor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008307 structural constituent of muscle
GO:0030898 actin-dependent ATPase activity
Biological Process
GO:0006200 ATP catabolic process
GO:0006936 muscle contraction
GO:0007411 axon guidance
GO:0007519 skeletal muscle tissue development
GO:0008152 metabolic process
GO:0030049 muscle filament sliding
Cellular Component
GO:0005829 cytosol
GO:0016020 membrane
GO:0016459 myosin complex
GO:0016461 unconventional myosin complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000090841
View Gene Order
ENSBTAG00000010799
Not yet available
Pathways
NETPATH
REACTOME
REACT_19277
Sema4D induced cell migration and growth-cone collapse pathway
REACT_19259
Sema4D in semaphorin signaling pathway
REACT_20558
Smooth Muscle Contraction pathway
REACT_111045
Developmental Biology pathway
REACT_19271
Semaphorin interactions pathway
REACT_18266
Axon guidance pathway
REACT_228063
EPHA-mediated growth cone collapse pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_17044
Muscle contraction pathway
KEGG
hsa04270
Vascular smooth muscle contraction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.733233
RefSeq NM_021019 NM_079423
HUGO
OMIM
CCDS CCDS31834 CCDS8906
HPRD 17618
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca