Version 5.4
Homo sapiens Gene: MAF1
Summary
InnateDB Gene IDBG-40110.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAF1
Gene Name MAF1 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000179632
Encoded Proteins
IDBP-40112
MAF1 homolog (S. cerevisiae)
IDBP-589725
MAF1 homolog (S. cerevisiae)
IDBP-590492
MAF1 homolog (S. cerevisiae)
IDBP-603352
MAF1 homolog (S. cerevisiae)
IDBP-591123
MAF1 homolog (S. cerevisiae)
IDBP-603351
MAF1 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is similar to Maf1, a Saccharomyces cerevisiae protein highly conserved in eukaryotic cells. Yeast Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:144104499-144107611
Strand Forward strand
Band q24.3
Transcripts
ENST00000322428 ENSP00000318604
ENST00000534585 ENSP00000433979
ENST00000532522 ENSP00000436720
ENST00000527572 ENSP00000431907
ENST00000527058 ENSP00000436030
ENST00000534811 ENSP00000436639
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001030 RNA polymerase III type 1 promoter DNA binding
GO:0001031 RNA polymerase III type 2 promoter DNA binding
GO:0001032 RNA polymerase III type 3 promoter DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0016480 negative regulation of transcription from RNA polymerase III promoter
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0060077 inhibitory synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022553
View Gene Order
ENSBTAG00000012242
Not yet available
Cross-References
SwissProt Q9H063
TrEMBL E9PJ05 E9PR76 E9PSH4 H0YEV4
UniProt Splice Variant
Entrez Gene 84232
UniGene Hs.19673
RefSeq NM_032272
HUGO HGNC:24966
OMIM 610210
CCDS CCDS6416
HPRD
IMGT
EMBL AC104592 AL136937 BC014082 BC018714 BC031273 CH471162 CR533463
GenPept AAH14082 AAH18714 AAH31273 CAB66871 CAG38494 EAW82158 EAW82159
RNA Seq Atlas 84232

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca