Version 5.4
Homo sapiens Gene: LSM6
Summary
InnateDB Gene IDBG-40113.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LSM6
Gene Name LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
Synonyms YDR378C
Species Homo sapiens
Ensembl Gene ENSG00000164167
Encoded Proteins
IDBP-40115
LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
IDBP-475137
LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
IDBP-480409
LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
IDBP-473932
LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:146175685-146200000
Strand Forward strand
Band q31.22
Transcripts
ENST00000296581 ENSP00000296581
ENST00000515311 ENSP00000427036
ENST00000503982
ENST00000502781 ENSP00000422392
ENST00000504181 ENSP00000420929
ENST00000510331
ENST00000507449
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
Experimentally validated
Total 38 [view]
Protein-Protein 38 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0006364 rRNA processing
GO:0006397 mRNA processing
GO:0008033 tRNA processing
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
Cellular Component
GO:0005681 spliceosomal complex
GO:0005829 cytosol
GO:0030532 small nuclear ribonucleoprotein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031683
View Gene Order
ENSBTAG00000014060
Not yet available
Pathways
NETPATH
REACTOME
REACT_20518
mRNA decay by 5' to 3' exoribonuclease pathway
REACT_20639
Deadenylation-dependent mRNA decay pathway
REACT_71
Gene Expression pathway
KEGG
hsa03018
RNA degradation pathway
hsa03040
Spliceosome pathway
INOH
PID NCI
Cross-References
SwissProt P62312
TrEMBL
UniProt Splice Variant
Entrez Gene 11157
UniGene Hs.190520
RefSeq NM_007080
HUGO HGNC:17017
OMIM 607286
CCDS CCDS3767
HPRD
IMGT
EMBL AC097372 AF182292 AJ238098 AK312126 BC016026 CH471056
GenPept AAD56230 AAH16026 AAY41032 BAG35062 CAB45869 EAX05029 EAX05030 EAX05031
RNA Seq Atlas 11157

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca