Version 5.4
Homo sapiens Gene: IL10RB
Summary
InnateDB Gene IDBG-401888.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL10RB
Gene Name interleukin 10 receptor, beta
Synonyms CDW210B; CRF2-4; CRFB4; D21S58; D21S66; IL-10R2
Species Homo sapiens
Ensembl Gene ENSG00000243646
Encoded Proteins
IDBP-2055
interleukin 10 receptor, beta
IDBP-362725
interleukin 10 receptor, beta
IDBP-362729
interleukin 10 receptor, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:33266358-33297234
Strand Forward strand
Band q22.11
Transcripts
ENST00000290200 ENSP00000290200
ENST00000422891 ENSP00000414682
ENST00000451065 ENSP00000397611
ENST00000493295
ENST00000498371
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 4 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0004920 interleukin-10 receptor activity
GO:0005515 protein binding
Biological Process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0019221 cytokine-mediated signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0032002 interleukin-28 receptor complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022969
View Gene Order
ENSBTAG00000019404
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa05145
Toxoplasmosis pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
IL-10 signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL F8WDX2
UniProt Splice Variant
Entrez Gene 3588
UniGene Hs.654593
RefSeq NM_000628
HUGO HGNC:5965
OMIM 123889
CCDS CCDS13623
HPRD 00473
IMGT
EMBL AP000295
GenPept
RNA Seq Atlas 3588

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca