Version 5.4
Homo sapiens Gene: PI4KA
Summary
InnateDB Gene IDBG-401917.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PI4KA
Gene Name phosphatidylinositol 4-kinase, catalytic, alpha
Synonyms PI4K-ALPHA; pi4K230; PIK4CA
Species Homo sapiens
Ensembl Gene ENSG00000241973
Encoded Proteins
IDBP-1796
phosphatidylinositol 4-kinase, catalytic, alpha
IDBP-231069
phosphatidylinositol 4-kinase, catalytic, alpha
IDBP-363966
phosphatidylinositol 4-kinase, catalytic, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. [provided by RefSeq, Sep 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:20707691-20859417
Strand Reverse strand
Band q11.21
Transcripts
ENST00000255882 ENSP00000255882
ENST00000399213 ENSP00000382162
ENST00000449120 ENSP00000402437
ENST00000492581
ENST00000477245
ENST00000466772
ENST00000482030
ENST00000466394
ENST00000489966
ENST00000485123
ENST00000462210
ENST00000494113
ENST00000477368
ENST00000475414
ENST00000466162
ENST00000484220
ENST00000485963
ENST00000485950
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004430 1-phosphatidylinositol 4-kinase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0007165 signal transduction
GO:0044281 small molecule metabolic process
GO:0046854 phosphatidylinositol phosphorylation
GO:0048015 phosphatidylinositol-mediated signaling
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030660 Golgi-associated vesicle membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041720
View Gene Order
ENSBTAG00000013971
Not yet available
Pathways
NETPATH
NetPath_11
TCR pathway
REACTOME
REACT_121168
Synthesis of PIPs at the ER membrane pathway
REACT_120836
Synthesis of PIPs at the Golgi membrane pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121175
PI Metabolism pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00562
Inositol phosphate metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
INOH
INOH website
Inositol phosphate metabolism pathway
PID NCI
avb3_integrin_pathway
Integrins in angiogenesis
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.529438 Hs.731386 Hs.736379 Hs.743784
RefSeq NM_002650 NM_058004
HUGO
OMIM
CCDS CCDS33603
HPRD 08972
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca