InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NAIP

Summary

InnateDB Gene

IDBG-402309.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NAIP

Gene Name

NLR family, apoptosis inhibitory protein

Synonyms

BIRC1; NLRB1; psiNAIP

Species

Homo sapiens

Ensembl Gene

ENSG00000249437

Encoded Proteins

IDBP-595795

NLR family, apoptosis inhibitory protein

IDBP-483620

NLR family, apoptosis inhibitory protein

IDBP-478479

NLR family, apoptosis inhibitory protein

IDBP-478277

NLR family, apoptosis inhibitory protein

IDBP-482441

NLR family, apoptosis inhibitory protein

IDBP-478608

NLR family, apoptosis inhibitory protein

IDBP-484275

NLR family, apoptosis inhibitory protein

IDBP-475282

NLR family, apoptosis inhibitory protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:70968483-71025114

Strand

Reverse strand

Band

q13.2

Transcripts

ENST00000315147
ENST00000194097	ENSP00000443944
ENST00000447012	ENSP00000429591
ENST00000517649	ENSP00000428657
ENST00000523981	ENSP00000428363
ENST00000508426	ENSP00000429545
ENST00000514857	ENSP00000428226
ENST00000508794
ENST00000519014	ENSP00000429154
ENST00000503719	ENSP00000424913

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0017111	nucleoside-triphosphatase activity
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0046872	metal ion binding

Biological Process

GO:0006954	inflammatory response
GO:0007399	nervous system development
GO:0008152	metabolic process
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0045087	innate immune response

Cellular Component

GO:0005737	cytoplasm
GO:0016323	basolateral plasma membrane
GO:0070062	extracellular vesicular exosome

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

KEGG

hsa04621

NOD-like receptor signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

Q13075

TrEMBL

B4DHI2

UniProt Splice Variant

Entrez Gene

4671

UniGene

Hs.606815 Hs.652859 Hs.654500 Hs.658700 Hs.667693 Hs.710305 Hs.737896

RefSeq

NM_022892 NM_004536 XM_005248523 XM_006714628 XM_006714629 XM_006714630

HUGO

HGNC:7634

OMIM

600355

CCDS

CCDS43327 CCDS4009

HPRD

IMGT

EMBL

AB048534 AB209123 AC005031 AC044797 AH003063 AK295115 BC136273 U19251 U80017

GenPept

AAA64504 AAC52045 AAC52047 AAC62261 AAI36274 BAB87181 BAD92360 BAG58144

RNA Seq Atlas

4671