Version 5.4
Homo sapiens Gene: APOBEC3D
Summary
InnateDB Gene IDBG-402334.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APOBEC3D
Gene Name apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000243811
Encoded Proteins
IDBP-7937
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D
IDBP-7939
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D
IDBP-377024
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D
IDBP-808414
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the cytidine deaminase gene family. It is one of a group of related genes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1 and inhibit retroviruses, such as HIV, by deaminating cytosine residues in nascent retroviral cDNA. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:39014363-39033276
Strand Forward strand
Band q13.1
Transcripts
ENST00000216099 ENSP00000216099
ENST00000381568 ENSP00000370980
ENST00000427494 ENSP00000388017
ENST00000622217 ENSP00000480718
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0008270 zinc ion binding
GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Biological Process
GO:0008152 metabolic process
GO:0010529 negative regulation of transposition
GO:0045087 innate immune response
GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0051607 defense response to virus
GO:0070383 DNA cytosine deamination
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005737 cytoplasm
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.597374 Hs.629775 Hs.658626
RefSeq NM_152426 XM_005261335 XM_005261337
HUGO
OMIM
CCDS CCDS46709
HPRD 16501
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca