Version 5.4
Homo sapiens Gene: RPP21
Summary
InnateDB Gene IDBG-402444.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPP21
Gene Name ribonuclease P/MRP 21kDa subunit
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000241370
Encoded Proteins
IDBP-368582
ribonuclease P/MRP 21kDa subunit
IDBP-368583
ribonuclease P/MRP 21kDa subunit
IDBP-368584
ribonuclease P/MRP 21kDa subunit
IDBP-368585
ribonuclease P/MRP 21kDa subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary RPP21 is a protein subunit of nuclear ribonuclease P, which processes the 5-prime leader sequence of precursor tRNAs (Jarrous et al., 2001 [PubMed 11497433]).[supplied by OMIM, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:30345131-30346884
Strand Forward strand
Band p22.1
Transcripts
ENST00000433076 ENSP00000409799
ENST00000442966 ENSP00000403833
ENST00000436442 ENSP00000397778
ENST00000428040 ENSP00000394320
ENST00000466327
ENST00000498414
ENST00000489124
ENST00000491477
ENST00000473266
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 2 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004526 ribonuclease P activity
GO:0046872 metal ion binding
Biological Process
GO:0008033 tRNA processing
GO:0042493 response to drug
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0005730 nucleolus
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000024446
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
hsa03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt Q9H633
TrEMBL
UniProt Splice Variant
Entrez Gene 79897
UniGene Hs.183232 Hs.615176
RefSeq NM_024839 NM_001199120 NM_001199121
HUGO HGNC:21300
OMIM 612524
CCDS CCDS4679 CCDS56409 CCDS56410
HPRD 15275
IMGT
EMBL AF212152 AJ504713 AJ504714 AJ504715 AJ504716 AK026291 AL662795 AL662832 AL773535 BC011730 BI598757 BX294158 BX927214 CH471081 CR759281 CR759928
GenPept AAH11730 AAK39955 BAB15433 CAD44289 CAD44290 CAD44291 CAD44292 CAI17503 CAI17506 CAI17507 CAI18254 CAI18255 CAI41822 CAI41824 CAM25559 CAM25886 CAM25887 CAM25888 CAM25889 CAQ08317 CAQ08318 CAQ08386 CAQ08387 CAQ08388 CAQ09024 CAQ09025 EAX03287 EAX03288 EAX03289
RNA Seq Atlas 79897

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca