Homo sapiens Gene: CDKN2B-AS1 | |||
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Summary | |||
InnateDB Gene | IDBG-403373.4 | ||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||
Gene Symbol | CDKN2B-AS1 | ||
Gene Name | CDKN2B antisense RNA 1 | ||
Synonyms | |||
Species | Homo sapiens | ||
Ensembl Gene | ENSG00000240498 | ||
Encoded Proteins | |||
Protein Structure | |||
Useful resources | Stemformatics EHFPI ImmGen | ||
Entrez Gene | |||
Summary |
This gene is located within the CDKN2B-CDKN2A gene cluster at chromosome 9p21 locus, which is the strongest genetic susceptibility locus for cardiovascular diseases, and also linked to several cancers, intracranial aneurysm, type-2 diabetes, periodontitis, Alzheimer's disease, endometriosis, frailty in the elderly, and glaucoma. Many disease-associated single-nucleotide polymorphisms in this locus affect the structure and expression of this gene, suggesting that modulation of this gene expression mediates disease susceptibility. This gene interacts with both polycomb repressive complex-1 (PRC1) and -2 (PRC2), and may function as a regulator for epigenetic transcriptional repression. Multiple alternatively spliced transcript variants have been generated from this gene, and all of them are long non-coding RNAs. It has been found that some of splice variants are tissue specific, and different splice variants may have distinct roles in cell physiology. [provided by RefSeq, Jun 2012] |
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Gene Information | |||
Type | antisense | ||
Genomic Location | Chromosome 9:21994778-22121097 | ||
Strand | Forward strand | ||
Band | p21.3 | ||
Transcripts | |||
Interactions | |||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Orthologs | |||
No orthologs found for this gene | |||
Cross-References | |||
SwissProt | |||
TrEMBL | |||
UniProt Splice Variant | |||
Entrez Gene | |||
UniGene | Hs.493614 | ||
RefSeq | |||
HUGO | |||
OMIM | |||
CCDS | |||
HPRD | |||
IMGT | |||
EMBL | |||
GenPept | |||
RNA Seq Atlas | |||