InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IRF5

Summary

InnateDB Gene

IDBG-40393.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IRF5

Gene Name

interferon regulatory factor 5

Synonyms

SLEB10

Species

Homo sapiens

Ensembl Gene

ENSG00000128604

Encoded Proteins

IDBP-40395

interferon regulatory factor 5

IDBP-40399

interferon regulatory factor 5

IDBP-294353

interferon regulatory factor 5

IDBP-479144

interferon regulatory factor 5

IDBP-483540

interferon regulatory factor 5

IDBP-479097

interferon regulatory factor 5

IDBP-483208

interferon regulatory factor 5

IDBP-484838

interferon regulatory factor 5

IDBP-481932

interferon regulatory factor 5

IDBP-477223

interferon regulatory factor 5

IDBP-476452

interferon regulatory factor 5

IDBP-813057

interferon regulatory factor 5

IDBP-813063

interferon regulatory factor 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 18332133

IRF5 is activated by both TBK1 and MYD88 to form a homodimer that binds to and activates transcription of type I interferon and inflammatory cytokine genes.

PMID 12600985

IRF5 can act as both an activator and a repressor of interferon (IFN) gene induction dependent on the IRF-interacting partner, and may be a part of the regulatory network that ensures timely expression of the immediate early inflammatory genes.

PMID 22412986

Phosphorylation of IRF5 at ser451 and ser462 is the primary trigger of IRF5 function in nuclear accumulation, transcription and apoptosis.

InnateDB Annotation from Orthologs

Summary

PMID 22412986

[Mus musculus] Phosphorylation of Irf5 at ser451 and ser462 is the primary trigger of Irf5 function in nuclear accumulation, transcription and apoptosis. (Demonstrated in human)

PMID 25031348

[Mus musculus] Irf5 modulates West Nile virus pathogenesis and host immune responses by shaping the early pro-inflammatory cytokine response in the draining lymph node.

PMID 25565375

[Mus musculus] Traf2 mediates proteasome-dependent degradation of Irf5 and Rel as well as regulating macrophage polarization in tumour microenvironment and controlling tumour growth.

Entrez Gene

Summary

This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Multiple transcript variants encoding different isoforms have been found for this gene, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:128937612-128950035

Strand

Forward strand

Band

q32.1

Transcripts

ENST00000357234	ENSP00000349770
ENST00000249375	ENSP00000249375
ENST00000402030	ENSP00000385352
ENST00000489702	ENSP00000418037
ENST00000488569
ENST00000477535	ENSP00000419950
ENST00000479582	ENSP00000417770
ENST00000464557	ENSP00000419056
ENST00000461416
ENST00000473787	ENSP00000420274
ENST00000467002	ENSP00000417454
ENST00000473745	ENSP00000419149
ENST00000465603	ENSP00000418534
ENST00000613821	ENSP00000480058
ENST00000619830	ENSP00000483292

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 74 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	74 [view]
Protein-Protein	60 [view]
Protein-DNA	12 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000975	regulatory region DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0019221	cytokine-mediated signaling pathway
GO:0032494	response to peptidoglycan
GO:0032495	response to muramyl dipeptide
GO:0032727	positive regulation of interferon-alpha production
GO:0032728	positive regulation of interferon-beta production
GO:0032735	positive regulation of interleukin-12 production
GO:0043065	positive regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051607	defense response to virus
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0060337	type I interferon signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000029771

View Gene Order

ENSBTAG00000004989

Not yet available

Pathways

NETPATH

REACTOME

REACT_25162

Interferon alpha/beta signaling pathway

REACT_25078

Interferon gamma signaling pathway

REACT_75790

Cytokine Signaling in Immune system pathway

REACT_25229

Interferon Signaling pathway

REACT_6900

Immune System pathway

KEGG

hsa04620

Toll-like receptor signaling pathway pathway

INOH

PID NCI

p53downstreampathway

Direct p53 effectors

Cross-References

SwissProt

Q13568

TrEMBL

A0A024R756 A0A024R763 C9J7M2 C9JAU6 C9JB67 C9JYP7 F8WDH6 I6ZU14 Q64GB0

UniProt Splice Variant

Entrez Gene

3663

UniGene

Hs.614535

RefSeq

NM_001098627 NM_001098629 NM_001098630 NM_001242452 NM_032643 XM_005250317 XM_006715974

HUGO

HGNC:6120

OMIM

607218

CCDS

CCDS43645 CCDS56512 CCDS5808

HPRD

IMGT

EMBL

AC025594 AY504946 AY504947 AY693665 AY693666 AY693667 AY693668 BC004139 BC004201 CH236950 CH471070 DQ277633 DQ277634 DQ995495 DQ995496 EF064718 JQ950681 U51127

GenPept

AAA96056 AAH04139 AAH04201 AAR90325 AAR90326 AAU12877 AAU12878 AAU12879 AAU12880 ABB88960 ABB88961 ABK41901 ABL96293 ABL96294 AFN70752 EAL24107 EAL24108 EAW83703 EAW83704 EAW83705 EAW83706 EAW83707

RNA Seq Atlas

3663