Version 5.4
Homo sapiens Gene: IL17RB
Summary
InnateDB Gene IDBG-40441.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL17RB
Gene Name interleukin 17 receptor B
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000056736
Encoded Proteins
IDBP-40445
interleukin 17 receptor B
IDBP-478778
interleukin 17 receptor B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:53846580-53865800
Strand Forward strand
Band p21.1
Transcripts
ENST00000288167 ENSP00000288167
ENST00000475124
ENST00000494338 ENSP00000418638
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004896 cytokine receptor activity
Biological Process
GO:0001558 regulation of cell growth
GO:0006952 defense response
GO:0019221 cytokine-mediated signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000015966
View Gene Order
ENSBTAG00000011178
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt Q9NRM6
TrEMBL C9IZN0
UniProt Splice Variant
Entrez Gene 55540
UniGene Hs.654970
RefSeq NM_018725
HUGO HGNC:18015
OMIM 605458
CCDS CCDS2874
HPRD
IMGT
EMBL AC012467 AF208110 AF208111 AF212365 AF250309 AY359122 AY518533 BC000980
GenPept AAF78776 AAF86051 AAF86052 AAH00980 AAK37428 AAQ89956 AAR89910
RNA Seq Atlas 55540

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca