Version 5.4
Homo sapiens Gene: SLC39A5
Summary
InnateDB Gene IDBG-40452.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC39A5
Gene Name solute carrier family 39 (metal ion transporter), member 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000139540
Encoded Proteins
IDBP-40456
solute carrier family 39 (metal ion transporter), member 5
IDBP-377779
solute carrier family 39 (metal ion transporter), member 5
IDBP-377783
solute carrier family 39 (metal ion transporter), member 5
IDBP-377785
solute carrier family 39 (metal ion transporter), member 5
IDBP-377787
solute carrier family 39 (metal ion transporter), member 5
IDBP-377791
solute carrier family 39 (metal ion transporter), member 5
IDBP-377795
solute carrier family 39 (metal ion transporter), member 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A5 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:56230049-56237846
Strand Forward strand
Band q13.3
Transcripts
ENST00000266980 ENSP00000266980
ENST00000454355 ENSP00000405360
ENST00000419753 ENSP00000402891
ENST00000424625 ENSP00000404155
ENST00000417965 ENSP00000414868
ENST00000436633 ENSP00000391711
ENST00000437277 ENSP00000407399
ENST00000419232
ENST00000447080
ENST00000493574
ENST00000481103
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0046873 metal ion transmembrane transporter activity
Biological Process
GO:0006829 zinc ion transport
GO:0030001 metal ion transport
GO:0034224 cellular response to zinc ion starvation
GO:0055085 transmembrane transport
GO:0061351 neural precursor cell proliferation
GO:0070315 G1 to G0 transition involved in cell differentiation
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039878
View Gene Order
ENSBTAG00000002799
Not yet available
Pathways
NETPATH
REACTOME
REACT_20603
Zinc influx into cells by the SLC39 gene family pathway
REACT_20547
Metal ion SLC transporters pathway
REACT_19305
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_20530
Zinc transporters pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.591018
RefSeq NM_001135195 NM_173596 XM_005268803
HUGO
OMIM
CCDS CCDS8912
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca