InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HOXA10

Summary

InnateDB Gene

IDBG-404968.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HOXA10

Gene Name

homeobox A10

Synonyms

HOX1; HOX1.8; HOX1H; PL

Species

Homo sapiens

Ensembl Gene

ENSG00000253293

Encoded Proteins

IDBP-10524

homeobox A10

IDBP-237715

homeobox A10

IDBP-809806

homeobox A10

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the downstream homeobox A9 (HOXA9) gene. [provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:27170591-27180261

Strand

Reverse strand

Band

p15.2

Transcripts

ENST00000283921	ENSP00000283921
ENST00000396344	ENSP00000379633
ENST00000524368
ENST00000521421
ENST00000519593
ENST00000613671	ENSP00000479619

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	12 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0042826	histone deacetylase binding

Biological Process

GO:0001501	skeletal system development
GO:0006351	transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0007338	single fertilization
GO:0008584	male gonad development
GO:0009952	anterior/posterior pattern specification
GO:0009954	proximal/distal pattern formation
GO:0010468	regulation of gene expression
GO:0030326	embryonic limb morphogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060065	uterus development

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000000938

View Gene Order

ENSBTAG00000040082

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

hdac_classiii_pathway

Signaling events mediated by HDAC Class III

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.110637

RefSeq

NM_018951

HUGO

OMIM

CCDS

CCDS5410

HPRD

00845

IMGT

EMBL

GenPept

RNA Seq Atlas