InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GZMB

Summary

InnateDB Gene

IDBG-4054.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GZMB

Gene Name

granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)

Synonyms

CCPI; CGL-1; CGL1; CSP-B; CSPB; CTLA1; CTSGL1; HLP; SECT

Species

Homo sapiens

Ensembl Gene

ENSG00000100453

Encoded Proteins

IDBP-4056

granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)

IDBP-4058

granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)

IDBP-4060

granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)

IDBP-364712

granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)

IDBP-598232

granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)

IDBP-591224

granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)

IDBP-593278

granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)

IDBP-595394

granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)

IDBP-812059

granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response. [provided by RefSeq, Jul 2008]
Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface \'nonself\' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:24630954-24634267

Strand

Reverse strand

Band

q12

Transcripts

ENST00000382542	ENSP00000371982
ENST00000216341	ENSP00000216341
ENST00000382540	ENSP00000371980
ENST00000415355	ENSP00000387385
ENST00000532263	ENSP00000432074
ENST00000554242	ENSP00000450535
ENST00000530830	ENSP00000435084
ENST00000526004	ENSP00000434213
ENST00000616551	ENSP00000479643

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	79 [view]
Protein-Protein	77 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008236	serine-type peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0007219	Notch signaling pathway
GO:0008626	granzyme-mediated apoptotic signaling pathway
GO:0019835	cytolysis
GO:0097193	intrinsic apoptotic signaling pathway
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

Cellular Component

GO:0001772	immunological synapse
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0030141	secretory granule
GO:0043231	intracellular membrane-bounded organelle