InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SMO

Summary

InnateDB Gene

IDBG-40669.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMO

Gene Name

smoothened, frizzled family receptor

Synonyms

FZD11; Gx; SMOH

Species

Homo sapiens

Ensembl Gene

ENSG00000128602

Encoded Proteins

IDBP-40671

smoothened, frizzled family receptor

IDBP-484706

smoothened, frizzled family receptor

IDBP-483705

smoothened, frizzled family receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:129188872-129213545

Strand

Forward strand

Band

q32.1

Transcripts

ENST00000249373	ENSP00000249373
ENST00000462420	ENSP00000418720
ENST00000495998
ENST00000475779	ENSP00000420749

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005113	patched binding
GO:0005515	protein binding
GO:0008144	drug binding
GO:0017147	Wnt-protein binding
GO:0030165	PDZ domain binding
GO:0042813	Wnt-activated receptor activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001503	ossification
GO:0001570	vasculogenesis
GO:0001649	osteoblast differentiation
GO:0001701	in utero embryonic development
GO:0001708	cell fate specification
GO:0001755	neural crest cell migration
GO:0001947	heart looping
GO:0002052	positive regulation of neuroblast proliferation
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0003007	heart morphogenesis
GO:0003140	determination of left/right asymmetry in lateral mesoderm
GO:0003323	type B pancreatic cell development
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007224	smoothened signaling pathway
GO:0007228	positive regulation of hh target transcription factor activity
GO:0007283	spermatogenesis
GO:0007368	determination of left/right symmetry
GO:0007371	ventral midline determination
GO:0007389	pattern specification process
GO:0007417	central nervous system development
GO:0007494	midgut development
GO:0008284	positive regulation of cell proliferation
GO:0008406	gonad development
GO:0009952	anterior/posterior pattern specification
GO:0009953	dorsal/ventral pattern formation
GO:0010002	cardioblast differentiation
GO:0010468	regulation of gene expression
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0021508	floor plate formation
GO:0021561	facial nerve development
GO:0021696	cerebellar cortex morphogenesis
GO:0021794	thalamus development
GO:0021904	dorsal/ventral neural tube patterning
GO:0021910	smoothened signaling pathway involved in ventral spinal cord patterning
GO:0021938	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
GO:0021953	central nervous system neuron differentiation
GO:0021984	adenohypophysis development
GO:0030857	negative regulation of epithelial cell differentiation
GO:0031017	exocrine pancreas development
GO:0031069	hair follicle morphogenesis
GO:0031076	embryonic camera-type eye development
GO:0031102	neuron projection regeneration
GO:0032474	otolith morphogenesis
GO:0034504	protein localization to nucleus
GO:0035264	multicellular organism growth
GO:0042307	positive regulation of protein import into nucleus
GO:0042475	odontogenesis of dentin-containing tooth
GO:0042693	muscle cell fate commitment
GO:0043066	negative regulation of apoptotic process
GO:0043392	negative regulation of DNA binding
GO:0045880	positive regulation of smoothened signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048468	cell development
GO:0048557	embryonic digestive tract morphogenesis
GO:0048565	digestive tract development
GO:0048568	embryonic organ development
GO:0048589	developmental growth
GO:0048663	neuron fate commitment
GO:0048702	embryonic neurocranium morphogenesis
GO:0048703	embryonic viscerocranium morphogenesis
GO:0048741	skeletal muscle fiber development
GO:0048752	semicircular canal morphogenesis
GO:0048846	axon extension involved in axon guidance
GO:0048853	forebrain morphogenesis
GO:0050679	positive regulation of epithelial cell proliferation
GO:0050821	protein stabilization
GO:0051451	myoblast migration
GO:0051799	negative regulation of hair follicle development
GO:0060070	canonical Wnt signaling pathway
GO:0060248	detection of cell density by contact stimulus involved in contact inhibition
GO:0060413	atrial septum morphogenesis
GO:0060644	mammary gland epithelial cell differentiation
GO:0060684	epithelial-mesenchymal cell signaling
GO:0060830	ciliary receptor clustering involved in smoothened signaling pathway
GO:0061053	somite development
GO:0061113	pancreas morphogenesis
GO:0071397	cellular response to cholesterol
GO:0072001	renal system development
GO:0072285	mesenchymal to epithelial transition involved in metanephric renal vesicle formation
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis
GO:2000036	regulation of stem cell maintenance
GO:2000826	regulation of heart morphogenesis

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005901	caveola
GO:0005929	cilium
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043025	neuronal cell body
GO:0043231	intracellular membrane-bounded organelle
GO:0060170	ciliary membrane
GO:0070062	extracellular vesicular exosome
GO:0072372	primary cilium