Version 5.4
Homo sapiens Gene: PAN2
Summary
InnateDB Gene IDBG-40746.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAN2
Gene Name PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
Synonyms USP52
Species Homo sapiens
Ensembl Gene ENSG00000135473
Encoded Proteins
IDBP-40748
PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
IDBP-377920
PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
IDBP-377922
PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
IDBP-597338
PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
IDBP-586058
PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
IDBP-809384
PAN2 poly(A) specific ribonuclease subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3' to 5' exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3\' to 5\' exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:56316223-56334053
Strand Reverse strand
Band q13.3
Transcripts
ENST00000257931 ENSP00000257931
ENST00000425394 ENSP00000401721
ENST00000440411 ENSP00000388231
ENST00000551359
ENST00000547226
ENST00000548043 ENSP00000449861
ENST00000553230
ENST00000547100
ENST00000549090
ENST00000550028
ENST00000552630
ENST00000549348
ENST00000547994
ENST00000552868
ENST00000548982
ENST00000549073
ENST00000550555
ENST00000547572 ENSP00000449092
ENST00000547518
ENST00000549964
ENST00000610546 ENSP00000481859
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 344 experimentally validated interaction(s) in this database.
Experimentally validated
Total 344 [view]
Protein-Protein 343 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000175 3'-5'-exoribonuclease activity
GO:0003676 nucleic acid binding
GO:0004527 exonuclease activity
GO:0004535 poly(A)-specific ribonuclease activity
GO:0005515 protein binding
GO:0036459 ubiquitinyl hydrolase activity
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005634 nucleus
GO:0005829 cytosol
GO:0031251 PAN complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005682
View Gene Order
ENSBTAG00000004376
Not yet available
Pathways
NETPATH
REACTOME
REACT_20514
Deadenylation of mRNA pathway
REACT_20639
Deadenylation-dependent mRNA decay pathway
REACT_71
Gene Expression pathway
KEGG
hsa03018
RNA degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.273397
RefSeq NM_001127460 NM_001166279 NM_014871
HUGO
OMIM
CCDS CCDS44922 CCDS53802 CCDS8915
HPRD 15640
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca