InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CPSF1

Summary

InnateDB Gene

IDBG-40804.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CPSF1

Gene Name

cleavage and polyadenylation specific factor 1, 160kDa

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000071894

Encoded Proteins

IDBP-807617

cleavage and polyadenylation specific factor 1, 160kDa

IDBP-807653

cleavage and polyadenylation specific factor 1, 160kDa

IDBP-603950

cleavage and polyadenylation specific factor 1, 160kDa

IDBP-807651

cleavage and polyadenylation specific factor 1, 160kDa

IDBP-807657

cleavage and polyadenylation specific factor 1, 160kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 [PubMed 7590244]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:144393229-144409349

Strand

Reverse strand

Band

q24.3

Transcripts

ENST00000531480
ENST00000531727	ENSP00000483775
ENST00000532725
ENST00000526271
ENST00000532935	ENSP00000478161
ENST00000529288
ENST00000527827
ENST00000527916
ENST00000533492
ENST00000532560
ENST00000531042	ENSP00000435761
ENST00000620219	ENSP00000478145
ENST00000622776
ENST00000616140	ENSP00000484669

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	57 [view]
Protein-Protein	55 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003730	mRNA 3'-UTR binding
GO:0005515	protein binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0006378	mRNA polyadenylation
GO:0006379	mRNA cleavage
GO:0006406	mRNA export from nucleus
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0031124	mRNA 3'-end processing