Homo sapiens Gene: CORT | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-408494.3 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | CORT | ||||||||||||||||||
Gene Name | cortistatin | ||||||||||||||||||
Synonyms | CST-14; CST-17; CST-29 | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000241563 | ||||||||||||||||||
Encoded Proteins |
cortistatin
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
This gene encodes a neuropeptide that is structurally similar to somatostatin. It binds to all known somatostatin receptors, and shares many pharmacological and functional properties with somatostatin, including the depression of neuronal activity. However, it also has many properties distinct from somatostatin, such as induction of slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor activity, and activation of cation selective currents not responsive to somatostatin. The preproprotein undergoes further processing into multiple mature products. Read-through transcripts exist between this gene and the upstream APITD1 (apoptosis-inducing, TAF9-like domain 1) gene, as represented in GeneID:100526739. [provided by RefSeq, Nov 2010] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 1:10449719-10451902 | ||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||
Band | p36.22 | ||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Cross-References | |||||||||||||||||||
SwissProt | O00230 | ||||||||||||||||||
TrEMBL | Q8IUV6 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 1325 | ||||||||||||||||||
UniGene | |||||||||||||||||||
RefSeq | NM_001302 | ||||||||||||||||||
HUGO | HGNC:2257 | ||||||||||||||||||
OMIM | 602784 | ||||||||||||||||||
CCDS | CCDS117 | ||||||||||||||||||
HPRD | 04150 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AB000263 AF013252 AL354956 AY358561 BC040034 BC119724 BC119725 CH471130 | ||||||||||||||||||
GenPept | AAB66895 AAH40034 AAI19725 AAI19726 AAQ89950 BAA19770 CAI19195 EAW71650 | ||||||||||||||||||
RNA Seq Atlas | 1325 | ||||||||||||||||||