Homo sapiens Gene: NRF1

Summary
InnateDB Gene IDBG-40856.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol NRF1
Gene Name nuclear respiratory factor 1
Synonyms ALPHA-PAL
Species Homo sapiens
Ensembl Gene ENSG00000106459
Encoded Proteins
IDBP-40858 nuclear respiratory factor 1
IDBP-40860 nuclear respiratory factor 1
IDBP-40862 nuclear respiratory factor 1
IDBP-244037 nuclear respiratory factor 1
IDBP-244039 nuclear respiratory factor 1
IDBP-244041 nuclear respiratory factor 1
IDBP-386241 nuclear respiratory factor 1
IDBP-601903 nuclear respiratory factor 1
Entrez Gene
Summary This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7: 129251555-129396922
Strand Forward strand
Band q32.2
Transcripts
ENST00000311967  ENSP00000309826
ENST00000223190  ENSP00000223190
ENST00000353868  ENSP00000342351
ENST00000393232  ENSP00000376924
ENST00000393231  ENSP00000376923
ENST00000393230  ENSP00000376922
ENST00000454688  ENSP00000394877
ENST00000477428 
ENST00000539636  ENSP00000440455
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein‑Protein  11
[view]
Protein‑DNA 1
[view]
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Predicted by orthology
Total [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0003677 DNA binding
Biological Process
GO:0001666 response to hypoxia
GO:0006091 generation of precursor metabolites and energy
GO:0006351 transcription, DNA-dependent
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007005 mitochondrion organization
GO:0031100 organ regeneration
GO:0032355 response to estradiol stimulus
GO:0032496 response to lipopolysaccharide
GO:0051593 response to folic acid
GO:0051602 response to electrical stimulus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000058440 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000014273 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
REACT_116145 PPARA Activates Gene Expression
KEGG
hsa05016  Huntington`s disease
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q16656 
TrEMBL B4DDV6 C9JP85 Q96AN2
UniProt Splice Variant
Entrez Gene 4899 
UniGene Hs.594964 Hs.606689 Hs.654363
RefSeq NM_001040110  NM_005011 
HUGO 7996 
OMIM 600879
CCDS CCDS5813 
HPRD 02930
IMGT
EMBL AC078846 AC084864 AK293351 BC016925 CH236950 CH471070 EU159452 L22454 U02683 U18375 U18376 U18377 U18378 U18379 U18380 U18381 U18382 U18383
GenPept AAA16918  AAA21647  AAA79013  AAH16925  ABV90872  BAG56867  EAL24100  EAW83728 
ImmGen NRF1 (murine) 
RNA Seq Atlas 4899