Homo sapiens Gene: NRF1
Summary
InnateDB Gene IDBG-40856.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NRF1
Gene Name nuclear respiratory factor 1
Synonyms ALPHA-PAL;
Species Homo sapiens
Ensembl Gene ENSG00000106459
Encoded Proteins
nuclear respiratory factor 1
nuclear respiratory factor 1
nuclear respiratory factor 1
nuclear respiratory factor 1
nuclear respiratory factor 1
nuclear respiratory factor 1
Protein Structure
Entrez Gene
Summary This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, Jul 2008]
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, May 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:129611714-129757082
Strand Forward strand
Band q32.2
Transcripts
ENST00000311967 ENSP00000309826
ENST00000223190 ENSP00000223190
ENST00000353868 ENSP00000342351
ENST00000393232 ENSP00000376924
ENST00000393230 ENSP00000376922
ENST00000454688 ENSP00000394877
ENST00000477428
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 14 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
Biological Process
GO:0001666 response to hypoxia
GO:0006091 generation of precursor metabolites and energy
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007005 mitochondrion organization
GO:0031100 organ regeneration
GO:0032355 response to estradiol
GO:0032496 response to lipopolysaccharide
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051593 response to folic acid
GO:0051602 response to electrical stimulus
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Organelle biogenesis and maintenance pathway
Metabolism of lipids and lipoproteins pathway
Mitochondrial biogenesis pathway
PPARA activates gene expression pathway
Transcriptional activation of mitochondrial biogenesis pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
KEGG
Huntington's disease pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q16656
TrEMBL A0A024R770 A0A024R774 C9JP85
UniProt Splice Variant
Entrez Gene 4899
UniGene Hs.594964 Hs.606689 Hs.654363
RefSeq NM_001040110 NM_001293163 NM_005011
HUGO HGNC:7996
OMIM 600879
CCDS CCDS5813
HPRD 02930
IMGT
EMBL AC078846 AC084864 AK290891 AK293351 BC016925 CH236950 CH471070 EU159452 L22454 U02683 U18375 U18376 U18377 U18378 U18379 U18380 U18381 U18382 U18383
GenPept AAA16918 AAA21647 AAA79013 AAH16925 ABV90872 BAF83580 BAG56867 EAL24100 EAW83726 EAW83727 EAW83728 EAW83729 EAW83731
ImmGen NRF1 (murine)
RNA Seq Atlas 4899