Homo sapiens Gene: NRF1
Summary
InnateDB Gene IDBG-40856.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol NRF1
Gene Name nuclear respiratory factor 1
Synonyms ALPHA-PAL;
Species Homo sapiens
Ensembl Gene ENSG00000106459
Encoded Proteins
nuclear respiratory factor 1
nuclear respiratory factor 1
nuclear respiratory factor 1
nuclear respiratory factor 1
nuclear respiratory factor 1
nuclear respiratory factor 1
nuclear respiratory factor 1
nuclear respiratory factor 1
Protein Structure
Entrez Gene
Summary This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:129251555-129396922
Strand Forward strand
Band q32.2
Transcripts
ENST00000311967 ENSP00000309826
ENST00000223190 ENSP00000223190
ENST00000353868 ENSP00000342351
ENST00000393232 ENSP00000376924
ENST00000393231 ENSP00000376923
ENST00000393230 ENSP00000376922
ENST00000454688 ENSP00000394877
ENST00000477428
ENST00000539636 ENSP00000440455
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
Biological Process
GO:0001666 response to hypoxia
GO:0006091 generation of precursor metabolites and energy
GO:0006351 transcription, DNA-dependent
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007005 mitochondrion organization
GO:0031100 organ regeneration
GO:0032355 response to estradiol stimulus
GO:0032496 response to lipopolysaccharide
GO:0051593 response to folic acid
GO:0051602 response to electrical stimulus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
PPARA Activates Gene Expression pathway
KEGG
Huntington`s disease pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q16656
TrEMBL B4DDV6 C9JP85 Q96AN2
UniProt Splice Variant
Entrez Gene 4899
UniGene Hs.594964 Hs.606689 Hs.654363
RefSeq NM_001040110 NM_005011
HUGO 7996
OMIM 600879
CCDS CCDS5813
HPRD 02930
IMGT
EMBL AC078846 AC084864 AK293351 BC016925 CH236950 CH471070 EU159452 L22454 U02683 U18375 U18376 U18377 U18378 U18379 U18380 U18381 U18382 U18383
GenPept AAA16918 AAA21647 AAA79013 AAH16925 ABV90872 BAG56867 EAL24100 EAW83728
ImmGen NRF1 (murine)
RNA Seq Atlas 4899