InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CEBPA

Summary

InnateDB Gene

IDBG-409028.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CEBPA

Gene Name

CCAAT/enhancer binding protein (C/EBP), alpha

Synonyms

C/EBP-alpha; CEBP

Species

Homo sapiens

Ensembl Gene

ENSG00000245848

Encoded Proteins

IDBP-478589

CCAAT/enhancer binding protein (C/EBP), alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21326902

[Mus musculus] Cebpa is a member of the CCAAT enhancer binding protein family and is a transcriptional factor regulating genes in innate immunity and inflammation. The activities of CEBP are regulated via methylation of arginine and lysine side chains.

PMID 25447519

[Mus musculus] Cebpa suppresses granule formation in mast cells and increases Cxcl2 production from mast cells upon bacterial stimulation.

Entrez Gene

Summary

The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells. [provided by RefSeq, Jul 2008]
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:33299934-33302564

Strand

Reverse strand

Band

q13.11

Transcripts

ENST00000498907

ENSP00000427514

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 145 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Experimentally validated
Total	145 [view]
Protein-Protein	123 [view]
Protein-DNA	18 [view]
Protein-RNA	0
DNA-DNA	4 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019904	protein domain specific binding
GO:0032403	protein complex binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity
GO:0071837	HMG box domain binding

Biological Process

GO:0000050	urea cycle
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001889	liver development
GO:0001892	embryonic placenta development
GO:0006091	generation of precursor metabolites and energy
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006953	acute-phase response
GO:0007005	mitochondrion organization
GO:0007584	response to nutrient
GO:0008203	cholesterol metabolic process
GO:0008285	negative regulation of cell proliferation
GO:0016032	viral process
GO:0019221	cytokine-mediated signaling pathway
GO:0030099	myeloid cell differentiation
GO:0030154	cell differentiation
GO:0030225	macrophage differentiation
GO:0030324	lung development
GO:0031100	organ regeneration
GO:0033274	response to vitamin B2
GO:0042127	regulation of cell proliferation
GO:0045087	innate immune response (InnateDB)
GO:0045444	fat cell differentiation
GO:0045600	positive regulation of fat cell differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045945	positive regulation of transcription from RNA polymerase III promoter
GO:0048469	cell maturation
GO:0048839	inner ear development
GO:0050872	white fat cell differentiation
GO:0050873	brown fat cell differentiation
GO:0051384	response to glucocorticoid
GO:0071285	cellular response to lithium ion
GO:0071407	cellular response to organic cyclic compound