Version 5.4
Homo sapiens Gene: STAT2
Summary
InnateDB Gene IDBG-40906.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STAT2
Gene Name signal transducer and activator of transcription 2, 113kDa
Synonyms ISGF-3; P113; STAT113
Species Homo sapiens
Ensembl Gene ENSG00000170581
Encoded Proteins
IDBP-40908
signal transducer and activator of transcription 2, 113kDa
IDBP-377969
signal transducer and activator of transcription 2, 113kDa
IDBP-591716
signal transducer and activator of transcription 2, 113kDa
IDBP-588316
signal transducer and activator of transcription 2, 113kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 8943351
STAT2 is part of STAT-containing transcription factor, the alpha-interferon-induced ISGF3, that is composed of a STAT1:2 heterodimer and a weak DNA-binding protein, IRF9.
PMID 16689942
STAT2 is a critical transactivator component of the interferon-stimulated gene factor 3 (ISGF3) complex that drives the expression of many interferon (IFN)-inducible genes.
PMID 23391734
A loss-of-function mutation in STAT2 is associated with increased susceptibility to childhood viral diseases.
InnateDB Annotation from Orthologs
Summary
PMID 26335850
[Mus musculus] Transcriptional activation of Adar by IFN occurs in the absence of Stat1 by a non-canonical Stat2-dependent pathway.
Entrez Gene
Summary The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:56341597-56360155
Strand Reverse strand
Band q13.3
Transcripts
ENST00000314128 ENSP00000315768
ENST00000418572 ENSP00000387354
ENST00000556539
ENST00000557235 ENSP00000450751
ENST00000555488
ENST00000557199
ENST00000555519
ENST00000557252
ENST00000556140
ENST00000557156
ENST00000557417
ENST00000555646 ENSP00000450985
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Experimentally validated
Total 79 [view]
Protein-Protein 45 [view]
Protein-DNA 33 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004871 signal transducer activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0007259 JAK-STAT cascade
GO:0016032 viral process
GO:0019221 cytokine-mediated signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0051607 defense response to virus
GO:0060337 type I interferon signaling pathway
GO:0060338 regulation of type I interferon-mediated signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040033
View Gene Order
ENSBTAG00000004380
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_25216
Regulation of IFNA signaling pathway
REACT_25162
Interferon alpha/beta signaling pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_6900
Immune System pathway
KEGG
hsa04630
Jak-STAT signaling pathway pathway
hsa04062
Chemokine signaling pathway pathway
hsa04380
Osteoclast differentiation pathway
hsa05160
Hepatitis C pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
IFN alpha signaling pathway
PID NCI
cxcr4_pathway
CXCR4-mediated signaling events
il27pathway
IL27-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.530595
RefSeq NM_005419 NM_198332 XM_005269108 XM_005269109 XM_005269110 XM_005269111
HUGO
OMIM
CCDS CCDS55836 CCDS8917
HPRD 02778
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca