Version 5.4
Homo sapiens Gene: VPS28
Summary
InnateDB Gene IDBG-40909.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VPS28
Gene Name vacuolar protein sorting 28 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000160948
Encoded Proteins
IDBP-40911
vacuolar protein sorting 28 homolog (S. cerevisiae)
IDBP-40913
vacuolar protein sorting 28 homolog (S. cerevisiae)
IDBP-592092
vacuolar protein sorting 28 homolog (S. cerevisiae)
IDBP-588354
vacuolar protein sorting 28 homolog (S. cerevisiae)
IDBP-597905
vacuolar protein sorting 28 homolog (S. cerevisiae)
IDBP-594599
vacuolar protein sorting 28 homolog (S. cerevisiae)
IDBP-590197
vacuolar protein sorting 28 homolog (S. cerevisiae)
IDBP-594152
vacuolar protein sorting 28 homolog (S. cerevisiae)
IDBP-592809
vacuolar protein sorting 28 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein involved in endosomal sorting of cell surface receptors via a multivesicular body/late endosome pathway. The encoded protein is one of the three subunits of the ESCRT-I complex (endosomal complexes required for transport) involved in the sorting of ubiquitinated proteins. The two other subunits of ESCRT-I are vesicular protein sorting 23, also known as tumor susceptibility gene 101 (TSG101), and vesicular protein sorting 37. Two alternative transcripts encoding different isoforms have been described. Additional alternative transcripts may exist but the proteins encoded by these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:144423601-144428563
Strand Reverse strand
Band q24.3
Transcripts
ENST00000292510 ENSP00000292510
ENST00000377348 ENSP00000366565
ENST00000529182 ENSP00000434556
ENST00000526977
ENST00000526054 ENSP00000434064
ENST00000526204 ENSP00000433228
ENST00000530983
ENST00000528142
ENST00000530836 ENSP00000436102
ENST00000527797
ENST00000533806 ENSP00000431243
ENST00000531032 ENSP00000434393
ENST00000531924
ENST00000526734
ENST00000530790 ENSP00000432395
ENST00000524521
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0015031 protein transport
GO:0016032 viral process
GO:0016197 endosomal transport
GO:0019058 viral life cycle
GO:0019068 virion assembly
GO:0019082 viral protein processing
GO:0031397 negative regulation of protein ubiquitination
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0061024 membrane organization
GO:0075733 intracellular transport of virus
Cellular Component
GO:0000813 ESCRT I complex
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0031902 late endosome membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
null
View Gene Order
ENSBTAG00000026320
Not yet available
Pathways
NETPATH
REACTOME
REACT_115893
Membrane binding and targetting of GAG proteins pathway
REACT_6361
Late Phase of HIV Life Cycle pathway
REACT_27258
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
REACT_115860
Synthesis And Processing Of GAG, GAGPOL Polyproteins pathway
REACT_6256
HIV Life Cycle pathway
REACT_6185
HIV Infection pathway
REACT_6818
Assembly Of The HIV Virion pathway
REACT_6359
Budding and maturation of HIV virion pathway
REACT_116125
Disease pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt Q9UK41
TrEMBL E9PI55 E9PLM9 E9PQR7 E9PR04 Q548N1
UniProt Splice Variant
Entrez Gene 51160
UniGene Hs.418175
RefSeq NM_016208 NM_183057 XM_005272324
HUGO HGNC:18178
OMIM 611952
CCDS CCDS6425 CCDS34967
HPRD 11675
IMGT
EMBL AF182844 AF205589 AF316887 BC006485 BC019321 BC050713 CH471162
GenPept AAF00499 AAH06485 AAH19321 AAH50713 AAK00314 EAW82094 EAW82100
RNA Seq Atlas 51160

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca