Version 5.4
Homo sapiens Gene: TTC4
Summary
InnateDB Gene IDBG-409112.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TTC4
Gene Name tetratricopeptide repeat domain 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000243725
Encoded Proteins
IDBP-99040
tetratricopeptide repeat domain 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that contains tetratricopeptide (TPR) repeats. The 34-amino acid tetratricopeptide repeat motifs are found in a variety of proteins and may mediate protein-protein interactions and chaperone activity.[provided by RefSeq, Jun 2011]
This gene encodes a protein that contains tetratricopeptide (TPR) repeats, which often mediate protein-protein interactions and chaperone activity. The encoded protein interacts with heat shock proteins 70 and 90. Alternative splicing results in multiple transcript variants. Naturally-occuring readthrough transcription occurs from upstream gene MROH (maestro heat-like repeat family member 7) to this gene. [provided by RefSeq, Apr 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:54715822-54742657
Strand Forward strand
Band p32.3
Transcripts
ENST00000371284
ENST00000371281 ENSP00000360329
ENST00000486621
ENST00000486091
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 29 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025413
View Gene Order
ENSBTAG00000015931
Not yet available
Cross-References
SwissProt O95801
TrEMBL
UniProt Splice Variant
Entrez Gene 7268
UniGene Hs.729029
RefSeq NM_004623
HUGO HGNC:12394
OMIM 606753
CCDS CCDS596
HPRD 08417
IMGT
EMBL AF063602 AF073887 AK222562 AK292426 AL139244 BC001276 BT006817 CH471059
GenPept AAD19853 AAG43161 AAH01276 AAP35463 BAD96282 BAF85115 CAI18994 EAX06671
RNA Seq Atlas 7268

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca