Version 5.4
Homo sapiens Gene: PSG2
Summary
InnateDB Gene IDBG-409160.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PSG2
Gene Name pregnancy specific beta-1-glycoprotein 2
Synonyms CEA; PSBG2; PSG1
Species Homo sapiens
Ensembl Gene ENSG00000242221
Encoded Proteins
IDBP-54849
pregnancy specific beta-1-glycoprotein 2
IDBP-294492
pregnancy specific beta-1-glycoprotein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:43064211-43083045
Strand Reverse strand
Band q13.31
Transcripts
ENST00000329509 ENSP00000332984
ENST00000406487 ENSP00000385706
ENST00000491995
ENST00000593482
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0007565 female pregnancy
GO:0016477 cell migration
Cellular Component
GO:0005575 cellular_component
GO:0005576 extracellular region
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.594562 Hs.709200
RefSeq NM_031246
HUGO
OMIM
CCDS CCDS12616
HPRD 08891
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca