Homo sapiens Gene: ARHGEF3 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-40920.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | ARHGEF3 | ||||||||||||||||||
Gene Name | Rho guanine nucleotide exchange factor (GEF) 3 | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000163947 | ||||||||||||||||||
Encoded Proteins |
Rho guanine nucleotide exchange factor (GEF) 3
Rho guanine nucleotide exchange factor (GEF) 3
Rho guanine nucleotide exchange factor (GEF) 3
Rho guanine nucleotide exchange factor (GEF) 3
Rho guanine nucleotide exchange factor (GEF) 3
Rho guanine nucleotide exchange factor (GEF) 3
Rho guanine nucleotide exchange factor (GEF) 3
Rho guanine nucleotide exchange factor (GEF) 3
Rho guanine nucleotide exchange factor (GEF) 3
Rho guanine nucleotide exchange factor (GEF) 3
Rho guanine nucleotide exchange factor (GEF) 3
Rho guanine nucleotide exchange factor (GEF) 3
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 3:56727418-57079329 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | p14.3 | ||||||||||||||||||
Transcripts | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
NRAGE signals death through JNK pathway
G alpha (12/13) signalling events pathway
Rho GTPase cycle pathway
Signalling by NGF pathway
Signaling by Rho GTPases pathway
Signaling by GPCR pathway
p75 NTR receptor-mediated signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
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KEGG | |||||||||||||||||||
INOH | |||||||||||||||||||
PID NCI |
Regulation of RhoA activity
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Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | C9J586 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 50650 | ||||||||||||||||||
UniGene | Hs.476402 Hs.594648 Hs.608634 | ||||||||||||||||||
RefSeq | NM_001128615 NM_001128616 NM_001289698 NM_019555 XM_005265186 XM_005265187 XM_005265188 XM_005265189 | ||||||||||||||||||
HUGO | HGNC:683 | ||||||||||||||||||
OMIM | 612115 | ||||||||||||||||||
CCDS | CCDS2878 CCDS46854 CCDS46855 CCDS74948 | ||||||||||||||||||
HPRD | 12480 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC097358 AC099327 AC099559 AC099781 | ||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | 50650 | ||||||||||||||||||