Version 5.4
Homo sapiens Gene: PDCD6
Summary
InnateDB Gene IDBG-409259.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDCD6
Gene Name programmed cell death 6
Synonyms ALG-2; PEF1B
Species Homo sapiens
Ensembl Gene ENSG00000249915
Encoded Proteins
IDBP-10194
programmed cell death 6
IDBP-480561
programmed cell death 6
IDBP-482999
programmed cell death 6
IDBP-480843
programmed cell death 6
IDBP-484053
programmed cell death 6
IDBP-482343
programmed cell death 6
IDBP-474660
programmed cell death 6
IDBP-810124
programmed cell death 6
IDBP-810125
programmed cell death 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:271621-353856
Strand Forward strand
Band p15.33
Transcripts
ENST00000264933 ENSP00000264933
ENST00000515587
ENST00000513582
ENST00000505221 ENSP00000422085
ENST00000509581 ENSP00000422691
ENST00000507528 ENSP00000423815
ENST00000505526 ENSP00000424201
ENST00000506909 ENSP00000426003
ENST00000507473 ENSP00000425370
ENST00000511482
ENST00000512466
ENST00000614778 ENSP00000485024
ENST00000618970 ENSP00000482332
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 51 [view]
Protein-Protein 51 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0046983 protein dimerization activity
GO:0048306 calcium-dependent protein binding
GO:0060090 binding, bridging
Biological Process
GO:0001525 angiogenesis
GO:0001938 positive regulation of endothelial cell proliferation
GO:0006508 proteolysis
GO:0006886 intracellular protein transport
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010595 positive regulation of endothelial cell migration
GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032007 negative regulation of TOR signaling
GO:0034605 cellular response to heat
GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway
GO:0045766 positive regulation of angiogenesis
GO:0051592 response to calcium ion
GO:0051898 negative regulation of protein kinase B signaling
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0031410 cytoplasmic vesicle
GO:0031965 nuclear membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021576
View Gene Order
ENSBTAG00000046493
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001267556 NM_001267557 NM_001267558 NM_001267559 NM_013232
HUGO
OMIM
CCDS CCDS3854 CCDS58940 CCDS58941 CCDS75222 CCDS75223
HPRD 03035
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca