InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RBM14

Summary

InnateDB Gene

IDBG-409430.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RBM14

Gene Name

RNA binding motif protein 14

Synonyms

COAA; PSP2; SIP; SYTIP1; TMEM137

Species

Homo sapiens

Ensembl Gene

ENSG00000239306

Encoded Proteins

IDBP-59505

RNA binding motif protein 14

IDBP-242531

RNA binding motif protein 14

IDBP-292438

RNA binding motif protein 14

IDBP-292439

RNA binding motif protein 14

IDBP-379237

RNA binding motif protein 14

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a ribonucleoprotein that functions as a general nuclear coactivator, and an RNA splicing modulator. This protein contains two RNA recognition motifs (RRM) at the N-terminus, and multiple hexapeptide repeat domain at the C-terminus that interacts with thyroid hormone receptor-binding protein (TRBP), and is required for transcription activation. Alternatively spliced transcript variants encoding different isoforms (with opposing effects on transcription) have been described for this gene. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:66616582-66627347

Strand

Forward strand

Band

q13.2

Transcripts

ENST00000310137	ENSP00000311747
ENST00000393979	ENSP00000377548
ENST00000409738	ENSP00000386995
ENST00000409372	ENSP00000386518
ENST00000443702	ENSP00000414650
ENST00000511114
ENST00000512283
ENST00000460762
ENST00000461478
ENST00000496694

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 102 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	102 [view]
Protein-Protein	101 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0030674	protein binding, bridging
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0006366	transcription from RNA polymerase II promoter
GO:0009725	response to hormone
GO:0016575	histone deacetylation
GO:0030520	intracellular estrogen receptor signaling pathway
GO:0042921	glucocorticoid receptor signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0016592	mediator complex
GO:0030529	ribonucleoprotein complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000006456

View Gene Order

ENSBTAG00000001225

Not yet available

Cross-References

SwissProt

Q96PK6

TrEMBL

UniProt Splice Variant

Entrez Gene

10432

UniGene

Hs.533712 Hs.691913

RefSeq

NM_001198836 NM_001198837 NM_006328 NM_001198845 NM_001198846

HUGO

HGNC:14219

OMIM

612409

CCDS

CCDS55772 CCDS55773 CCDS8147 CCDS55774 CCDS55775

HPRD

11485

IMGT

EMBL

AF080561 AF315632 AF315633 AK021768 AK222830 AP001157 BC000488 BE885635 CH471076 CR749306 DQ294957 EU287938

GenPept

AAC64058 AAH00488 AAK77961 AAK77962 ABB99396 ABY74511 BAD96550 BAG51046 CAH18161 EAW74552

RNA Seq Atlas

10432