Homo sapiens Gene: KIR3DL3 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-409457.4 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | KIR3DL3 | ||||||||||||||||||
Gene Name | killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3 | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000242019 | ||||||||||||||||||
Encoded Proteins |
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 19:54724479-54736536 | ||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||
Band | q13.42 | ||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
No orthologs found for this gene | |||||||||||||||||||
Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME | |||||||||||||||||||
KEGG |
Antigen processing and presentation pathway
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INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q8N743 | ||||||||||||||||||
TrEMBL | K7RE68 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 115653 | ||||||||||||||||||
UniGene | |||||||||||||||||||
RefSeq | NM_153443 | ||||||||||||||||||
HUGO | HGNC:16312 | ||||||||||||||||||
OMIM | 610095 | ||||||||||||||||||
CCDS | CCDS12903 | ||||||||||||||||||
HPRD | |||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC006293 AF072407 AF072408 AF072409 AF072410 AF352324 AH011562 AH015396 AH015397 AL133414 AY083462 AY987937 AY987938 AY987939 AY987940 AY987941 AY987942 AY987943 EF153459 EF153460 EF153461 EF153462 EF153463 EF153464 EF153465 EF153466 EF153467 EF165005 EF165006 EF165007 EF165008 EF165009 EF175456 EF175457 EF175458 EF175459 EF175460 EF379094 EF379095 EF492034 EF492035 EF492036 EF492037 EF492038 EF492039 EF492040 EF492041 EF492042 EF492043 EF492044 JX008032 | ||||||||||||||||||
GenPept | AAC99763 AAD03159 AAK30258 AAM00023 AAM00024 ABC03226 ABC03227 ABC03228 ABC03229 ABC03230 ABC03231 ABC03232 ABC03233 ABC03234 ABM92653 ABM92654 ABM98078 ABM98079 ABM98080 ABM98081 ABM98082 ABM98083 ABM98084 ABM98085 ABM98086 ABM98087 ABM98088 ABM98089 ABM98090 ABM98091 ABM98092 ABM98093 ABM98094 ABM98095 ABM98096 ABS30929 ABS30930 ABS30931 ABS30932 ABS30933 ABS30934 ABS30935 ABS30936 ABS30937 ABS30938 ABS30939 AFV74780 CAC40702 | ||||||||||||||||||
RNA Seq Atlas | 115653 | ||||||||||||||||||