InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RPS3A

Summary

InnateDB Gene

IDBG-41024.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPS3A

Gene Name

ribosomal protein S3A

Synonyms

FTE1; MFTL; S3A

Species

Homo sapiens

Ensembl Gene

ENSG00000145425

Encoded Proteins

IDBP-41026

ribosomal protein S3A

IDBP-485197

ribosomal protein S3A

IDBP-477245

ribosomal protein S3A

IDBP-477865

ribosomal protein S3A

IDBP-482809

ribosomal protein S3A

IDBP-477558

ribosomal protein S3A

IDBP-485250

ribosomal protein S3A

IDBP-477126

ribosomal protein S3A

IDBP-485208

ribosomal protein S3A

IDBP-480116

ribosomal protein S3A

IDBP-474625

ribosomal protein S3A

IDBP-476916

ribosomal protein S3A

IDBP-484694

ribosomal protein S3A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S3AE family of ribosomal proteins. It is located in the cytoplasm. Disruption of the gene encoding rat ribosomal protein S3a, also named v-fos transformation effector protein, in v-fos-transformed rat cells results in reversion of the transformed phenotype. This gene is co-transcribed with the U73A and U73B small nucleolar RNA genes, which are located in its fourth and third introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:151099573-151104652

Strand

Forward strand

Band

q31.3

Transcripts

ENST00000274065	ENSP00000346050
ENST00000509736	ENSP00000422994
ENST00000507485
ENST00000505243	ENSP00000425024
ENST00000514682	ENSP00000421770
ENST00000515818	ENSP00000425978
ENST00000503002	ENSP00000421277
ENST00000512690	ENSP00000423953
ENST00000508783	ENSP00000421776
ENST00000512797	ENSP00000421457
ENST00000507327	ENSP00000424547
ENST00000515792	ENSP00000425508
ENST00000506126	ENSP00000426282
ENST00000510993	ENSP00000426466

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 182 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	182 [view]
Protein-Protein	181 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0002181	cytoplasmic translation
GO:0006412	translation
GO:0006413	translational initiation
GO:0006414	translational elongation
GO:0006415	translational termination
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019058	viral life cycle
GO:0019083	viral transcription
GO:0030154	cell differentiation
GO:0043066	negative regulation of apoptotic process
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022627	cytosolic small ribosomal subunit
GO:0030529	ribonucleoprotein complex
GO:0070062	extracellular vesicular exosome