Version 5.4
Homo sapiens Gene: PHLPP2
Summary
InnateDB Gene IDBG-41059.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PHLPP2
Gene Name PH domain and leucine rich repeat protein phosphatase 2
Synonyms PHLPPL
Species Homo sapiens
Ensembl Gene ENSG00000040199
Encoded Proteins
IDBP-243445
PH domain and leucine rich repeat protein phosphatase 2
IDBP-749988
IDBP-750148
IDBP-751126
IDBP-750887
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 16:71637835-71724701
Strand Reverse strand
Band q22.2
Transcripts
ENST00000393524 ENSP00000377159
ENST00000538126
ENST00000574977
ENST00000568954 ENSP00000457991
ENST00000567016 ENSP00000454519
ENST00000568004 ENSP00000458660
ENST00000564884 ENSP00000456572
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0008152 metabolic process
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0045087 innate immune response
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
Cellular Component
GO:0001917 photoreceptor inner segment
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0042622 photoreceptor outer segment membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031732
View Gene Order
ENSBTAG00000007545
Not yet available
Pathways
NETPATH
REACTOME
REACT_12447
Negative regulation of the PI3K/AKT network pathway
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_12464
PI3K/AKT activation pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21270
PI-3K cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_6802
Innate Immune System pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q6ZVD8
TrEMBL G3V1T8 H3BMS5 I3L187
UniProt Splice Variant
Entrez Gene 23035
UniGene Hs.709458
RefSeq NM_001289003 NM_015020
HUGO HGNC:29149
OMIM 611066
CCDS CCDS32479 CCDS73910
HPRD
IMGT
EMBL AB023148 AC009097 AK001854 AK124678 BC129927 BX647823 CH471166
GenPept AAI29928 BAA76775 BAA91943 BAC85924 EAW59225
RNA Seq Atlas 23035

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca