InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: APPL1

Summary

InnateDB Gene

IDBG-41092.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APPL1

Gene Name

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1

Synonyms

APPL; DIP13alpha

Species

Homo sapiens

Ensembl Gene

ENSG00000157500

Encoded Proteins

IDBP-41094

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1

IDBP-380246

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1

IDBP-481400

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:57227737-57273468

Strand

Forward strand

Band

p14.3

Transcripts

ENST00000288266	ENSP00000288266
ENST00000444459	ENSP00000406095
ENST00000482800
ENST00000495803	ENSP00000419644
ENST00000468342
ENST00000464446
ENST00000488530
ENST00000492501

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 59 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	59 [view]
Protein-Protein	56 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0043422	protein kinase B binding

Biological Process

GO:0006915	apoptotic process
GO:0007049	cell cycle
GO:0007165	signal transduction
GO:0008283	cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0046324	regulation of glucose import
GO:0090003	regulation of establishment of protein localization to plasma membrane

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0010008	endosome membrane
GO:0012506	vesicle membrane
GO:0016581	NuRD complex
GO:0031901	early endosome membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000040760

View Gene Order

ENSBTAG00000006824

Not yet available

Pathways

NETPATH

NetPath_2

AndrogenReceptor pathway

NetPath_4

EGFR1 pathway

NetPath_25

FSH pathway

REACTOME

REACT_22128

Role of DCC in regulating apoptosis pathway

REACT_578

Apoptosis pathway

REACT_13648

Regulation of Apoptosis pathway

KEGG

hsa05210

Colorectal cancer pathway

hsa05200

Pathways in cancer pathway

INOH

PID NCI

ar_pathway

Coregulation of Androgen receptor activity

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.476415 Hs.665154 Hs.666225

RefSeq

NM_012096

HUGO

OMIM

CCDS

CCDS2882

HPRD

05053

IMGT

EMBL

GenPept

RNA Seq Atlas