Version 5.4
Homo sapiens Gene: CPA2
Summary
InnateDB Gene IDBG-41197.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CPA2
Gene Name carboxypeptidase A2 (pancreatic)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000158516
Encoded Proteins
IDBP-41199
carboxypeptidase A2 (pancreatic)
IDBP-386284
carboxypeptidase A2 (pancreatic)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Three different forms of human pancreatic procarboxypeptidase A have been isolated. The encoded protein represents the A2 form, which is a monomeric protein with different biochemical properties from the A1 and A3 forms. The A2 form of pancreatic procarboxypeptidase acts on aromatic C-terminal residues and is a secreted protein. [provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:130266827-130289798
Strand Forward strand
Band q32.2
Transcripts
ENST00000222481 ENSP00000222481
ENST00000416698 ENSP00000395582
ENST00000480781
ENST00000487259
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004180 carboxypeptidase activity
GO:0004181 metallocarboxypeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0007039 vacuolar protein catabolic process
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000071553
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
hsa04972
Pancreatic secretion pathway
hsa04974
Protein digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.490038
RefSeq NM_001869
HUGO
OMIM
CCDS CCDS5817
HPRD 02821
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca