Version 5.4
Homo sapiens Gene: FBXW7
Summary
InnateDB Gene IDBG-41233.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXW7
Gene Name F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000109670
Encoded Proteins
IDBP-41235
F-box and WD repeat domain containing 7
IDBP-41237
F-box and WD repeat domain containing 7
IDBP-41239
F-box and WD repeat domain containing 7
IDBP-242551
F-box and WD repeat domain containing 7
IDBP-809062
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
IDBP-809064
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
IDBP-809065
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
IDBP-809066
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:152321259-152536101
Strand Reverse strand
Band q31.3
Transcripts
ENST00000281708 ENSP00000281708
ENST00000263981 ENSP00000263981
ENST00000296555 ENSP00000296555
ENST00000393956 ENSP00000377528
ENST00000603548 ENSP00000474725
ENST00000603821
ENST00000603841 ENSP00000474971
ENST00000604316
ENST00000604069
ENST00000604822
ENST00000604872 ENSP00000474751
ENST00000605042 ENSP00000474538
ENST00000604095
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 123 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 124 [view]
Protein-Protein 123 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0001570 vasculogenesis
GO:0001944 vasculature development
GO:0006355 regulation of transcription, DNA-templated
GO:0006974 cellular response to DNA damage stimulus
GO:0007062 sister chromatid cohesion
GO:0007219 Notch signaling pathway
GO:0010868 negative regulation of triglyceride biosynthetic process
GO:0010883 regulation of lipid storage
GO:0016032 viral process
GO:0016567 protein ubiquitination
GO:0030324 lung development
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0032876 negative regulation of DNA endoreduplication
GO:0032880 regulation of protein localization
GO:0034644 cellular response to UV
GO:0045741 positive regulation of epidermal growth factor-activated receptor activity
GO:0045746 negative regulation of Notch signaling pathway
GO:0050821 protein stabilization
GO:0055088 lipid homeostasis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000346 negative regulation of hepatocyte proliferation
GO:2000639 negative regulation of SREBP signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0019005 SCF ubiquitin ligase complex
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028086
View Gene Order
ENSBTAG00000007953
Not yet available
Pathways
NETPATH
NetPath_3
Notch pathway
NetPath_9
TNFalpha pathway
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_16907
Association of TriC/CCT with target proteins during biosynthesis pathway
REACT_16952
Protein folding pathway
REACT_17004
Chaperonin-mediated protein folding pathway
REACT_17015
Metabolism of proteins pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
INOH
INOH website
Notch signaling pathway pathway
PID NCI
myc_pathway
C-MYC pathway
deltanp63pathway
Validated transcriptional targets of deltaNp63 isoforms
notch_pathway
Notch signaling pathway
Cross-References
SwissProt Q969H0
TrEMBL A7BJS8 G0Z2K0 H9CWI2 H9CWI3 S4R3N3
UniProt Splice Variant
Entrez Gene 55294
UniGene
RefSeq NM_001013415 NM_001257069 NM_018315 NM_033632
HUGO HGNC:16712
OMIM 606278
CCDS CCDS3777 CCDS34078 CCDS3778 CCDS64082
HPRD
IMGT
EMBL AB333777 AC023424 AC080078 AF383178 AF411971 AF411972 AK001933 AY008274 AY033553 AY049984 BC037320 BC117244 BC117246 BC143944 CR749305 HQ873864 HQ873865 HQ873866 HQ873867 HQ873868 HQ873869 HQ873870 JQ410470 JQ410471
GenPept AAG16640 AAH37320 AAI17245 AAI17247 AAI43945 AAK57547 AAK60269 AAL06290 AAL06291 AAL07271 AEK48270 AEK48271 AEK48272 AEK48273 AEK48274 AEK48275 AEK48276 AFD64626 AFD64627 BAA91986 BAF73721 CAH18160
RNA Seq Atlas 55294

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca