Version 5.4
Homo sapiens Gene: IST1
Summary
InnateDB Gene IDBG-41285.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IST1
Gene Name increased sodium tolerance 1 homolog (yeast)
Synonyms OLC1
Species Homo sapiens
Ensembl Gene ENSG00000182149
Encoded Proteins
IDBP-41287
increased sodium tolerance 1 homolog (yeast)
IDBP-41289
increased sodium tolerance 1 homolog (yeast)
IDBP-41291
increased sodium tolerance 1 homolog (yeast)
IDBP-380511
increased sodium tolerance 1 homolog (yeast)
IDBP-380513
increased sodium tolerance 1 homolog (yeast)
IDBP-380515
increased sodium tolerance 1 homolog (yeast)
IDBP-751075
IDBP-751421
IDBP-746227
IDBP-750613
IDBP-753217
IDBP-750926
IDBP-754267
IDBP-753785
IDBP-749269
IDBP-753455
IDBP-595710
increased sodium tolerance 1 homolog (yeast)
IDBP-811731
increased sodium tolerance 1 homolog (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein with MIT-interacting motifs that interacts with components of endosomal sorting complexes required for transport (ESCRT). ESCRT functions in vesicle budding, such as that which occurs during membrane abscission in cytokinesis. There is a pseudogene for this gene on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:71845996-71931199
Strand Forward strand
Band q22.2
Transcripts
ENST00000378799 ENSP00000368076
ENST00000329908 ENSP00000330408
ENST00000378798 ENSP00000368075
ENST00000439924 ENSP00000410081
ENST00000424485 ENSP00000398505
ENST00000456820 ENSP00000414942
ENST00000540296 ENSP00000455409
ENST00000544564 ENSP00000457844
ENST00000541571 ENSP00000455860
ENST00000538104 ENSP00000455590
ENST00000537613 ENSP00000457646
ENST00000538565
ENST00000538850 ENSP00000463711
ENST00000541918 ENSP00000455805
ENST00000534994 ENSP00000454541
ENST00000539186 ENSP00000455757
ENST00000545518
ENST00000537571
ENST00000545388
ENST00000538709
ENST00000536027 ENSP00000463833
ENST00000541180
ENST00000535424 ENSP00000438399
ENST00000566536
ENST00000606369 ENSP00000475853
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0032403 protein complex binding
GO:0090541 MIT domain binding
Biological Process
GO:0000910 cytokinesis
GO:0008104 protein localization
GO:0009838 abscission
GO:0019076 viral release from host cell
GO:0045184 establishment of protein localization
GO:0045862 positive regulation of proteolysis
GO:0046745 viral capsid secondary envelopment
GO:0048672 positive regulation of collateral sprouting
GO:0051301 cell division
Cellular Component
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005813 centrosome
GO:0005829 cytosol
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030496 midbody
GO:0070062 extracellular vesicular exosome
GO:0090543 Flemming body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031729
View Gene Order
ENSBTAG00000019883
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001270975 NM_001270976 NM_001270977 NM_001270978 NM_001270979 NM_014761
HUGO
OMIM
CCDS CCDS10905 CCDS59271 CCDS59272 CCDS59273 CCDS59274
HPRD 13784
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca