Version 5.4
Homo sapiens Gene: PDE12
Summary
InnateDB Gene IDBG-41300.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDE12
Gene Name phosphodiesterase 12
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000174840
Encoded Proteins
IDBP-41302
phosphodiesterase 12
IDBP-480573
phosphodiesterase 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 26055709
PDE12 negatively regulates the innate immune response and inhibitors of PDE12 show increased IFN induced 2â??,5â??- oligoadenylate and antiviral activities.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 3:57556276-57566844
Strand Forward strand
Band p14.3
Transcripts
ENST00000311180 ENSP00000309142
ENST00000487257 ENSP00000420626
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004535 poly(A)-specific ribonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006397 mRNA processing
GO:0045087 innate immune response (InnateDB)
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000043702
View Gene Order
ENSBTAG00000015563
Not yet available
Cross-References
SwissProt Q6L8Q7
TrEMBL F6T1Q0
UniProt Splice Variant
Entrez Gene 201626
UniGene Hs.572993
RefSeq NM_177966
HUGO HGNC:25386
OMIM
CCDS CCDS33772
HPRD
IMGT
EMBL AB115695 AC092418 AK074423 AK300374 AL831824 CH471055
GenPept BAB85079 BAD20938 BAG62110 CAD38538 EAW65342
RNA Seq Atlas 201626

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca