Version 5.4
Homo sapiens Gene: PRKX
Summary
InnateDB Gene IDBG-41523.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRKX
Gene Name protein kinase, X-linked
Synonyms PKX1
Species Homo sapiens
Ensembl Gene ENSG00000183943
Encoded Proteins
IDBP-41525
protein kinase, X-linked
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25028512
MAP3K7 (TAK1) Ser412 phosphorylation is regulated by PRKACA and PRKX, and is essential for proper signalling, as well as proinflammatory cytokine induction by TLR/IL-1R activation.
Entrez Gene
Summary This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y. [provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:3604370-3713608
Strand Reverse strand
Band p22.33
Transcripts
ENST00000262848 ENSP00000262848
ENST00000425240
ENST00000462736
ENST00000496648
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004691 cAMP-dependent protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0001525 angiogenesis
GO:0001935 endothelial cell proliferation
GO:0006468 protein phosphorylation
GO:0007155 cell adhesion
GO:0018105 peptidyl-serine phosphorylation
GO:0030099 myeloid cell differentiation
GO:0030155 regulation of cell adhesion
GO:0030334 regulation of cell migration
GO:0031589 cell-substrate adhesion
GO:0043542 endothelial cell migration
GO:0045087 innate immune response (InnateDB)
GO:0046777 protein autophosphorylation
GO:0060562 epithelial tube morphogenesis
GO:0060993 kidney morphogenesis
GO:2000696 regulation of epithelial cell differentiation involved in kidney development
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035725
View Gene Order
ENSBTAG00000014367
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
hsa04912
GnRH signaling pathway pathway
hsa05110
Vibrio cholerae infection pathway
hsa04540
Gap junction pathway
hsa04310
Wnt signaling pathway pathway
hsa04740
Olfactory transduction pathway
hsa04340
Hedgehog signaling pathway pathway
hsa04210
Apoptosis pathway
hsa04010
MAPK signaling pathway pathway
hsa04720
Long-term potentiation pathway
hsa04910
Insulin signaling pathway pathway
hsa04742
Taste transduction pathway
hsa04020
Calcium signaling pathway pathway
hsa04916
Melanogenesis pathway
hsa05012
Parkinson's disease pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa04062
Chemokine signaling pathway pathway
hsa05020
Prion diseases pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa05414
Dilated cardiomyopathy pathway
hsa04962
Vasopressin-regulated water reabsorption pathway
hsa04114
Oocyte meiosis pathway
hsa04971
Gastric acid secretion pathway
hsa05146
Amoebiasis pathway
hsa04970
Salivary secretion pathway
hsa04976
Bile secretion pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.390788 Hs.619481
RefSeq NM_005044 XM_005274560
HUGO
OMIM
CCDS CCDS14125
HPRD 02097
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca