Version 5.4
Homo sapiens Gene: RPL8
Summary
InnateDB Gene IDBG-41561.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPL8
Gene Name ribosomal protein L8
Synonyms L8
Species Homo sapiens
Ensembl Gene ENSG00000161016
Encoded Proteins
IDBP-41563
ribosomal protein L8
IDBP-240593
ribosomal protein L8
IDBP-591617
ribosomal protein L8
IDBP-589161
ribosomal protein L8
IDBP-592805
ribosomal protein L8
IDBP-590109
ribosomal protein L8
IDBP-586092
ribosomal protein L8
IDBP-586955
ribosomal protein L8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein associates with the 5.8S rRNA, very likely participates in the binding of aminoacyl-tRNA, and is a constituent of the elongation factor 2-binding site at the ribosomal subunit interface. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:144789765-144792587
Strand Reverse strand
Band q24.3
Transcripts
ENST00000262584 ENSP00000262584
ENST00000394920 ENSP00000378378
ENST00000534781
ENST00000531975 ENSP00000437062
ENST00000529163
ENST00000526668
ENST00000528296
ENST00000527914 ENSP00000436460
ENST00000528957 ENSP00000433464
ENST00000529920 ENSP00000433703
ENST00000533397 ENSP00000435313
ENST00000532702 ENSP00000434535
ENST00000525232
ENST00000531767
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 124 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 124 [view]
Protein-Protein 122 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006412 translation
GO:0006413 translational initiation
GO:0006414 translational elongation
GO:0006415 translational termination
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0010467 gene expression
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0019058 viral life cycle
GO:0019083 viral transcription
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
GO:0005840 ribosome
GO:0016020 membrane
GO:0022625 cytosolic large ribosomal subunit
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003970
View Gene Order
ENSBTAG00000026327
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_79
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_75768
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) pathway
REACT_75822
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
REACT_2085
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_1797
Formation of a pool of free 40S subunits pathway
REACT_1986
Eukaryotic Translation Termination pathway
REACT_1404
Peptide chain elongation pathway
REACT_1477
Eukaryotic Translation Elongation pathway
REACT_115902
SRP-dependent cotranslational protein targeting to membrane pathway
REACT_9491
Viral mRNA Translation pathway
REACT_2159
Eukaryotic Translation Initiation pathway
REACT_6167
Influenza Infection pathway
REACT_75886
Nonsense-Mediated Decay (NMD) pathway
REACT_6152
Influenza Viral RNA Transcription and Replication pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_2099
Cap-dependent Translation Initiation pathway
REACT_6145
Influenza Life Cycle pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
KEGG
hsa03010
Ribosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_000973 NM_033301
HUGO
OMIM
CCDS CCDS6433
HPRD 16044
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca