InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FLNB

Summary

InnateDB Gene

IDBG-41570.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FLNB

Gene Name

filamin B, beta

Synonyms

ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L; LRS1; SCT; TABP; TAP

Species

Homo sapiens

Ensembl Gene

ENSG00000136068

Encoded Proteins

IDBP-41576

filamin B, beta

IDBP-41578

filamin B, beta

IDBP-380520

filamin B, beta

IDBP-380521

filamin B, beta

IDBP-476985

filamin B, beta

IDBP-473621

filamin B, beta

IDBP-476193

filamin B, beta

IDBP-475792

filamin B, beta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:58008400-58172251

Strand

Forward strand

Band

p14.3

Transcripts

ENST00000295956	ENSP00000295956
ENST00000358537	ENSP00000351339
ENST00000429972	ENSP00000415599
ENST00000419752	ENSP00000414532
ENST00000490882	ENSP00000420213
ENST00000493452	ENSP00000418510
ENST00000481470
ENST00000491408
ENST00000477629
ENST00000466455	ENSP00000420199
ENST00000470231	ENSP00000419954
ENST00000468939
ENST00000475487
ENST00000484981

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	70 [view]
Protein-Protein	70 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0007016	cytoskeletal anchoring at plasma membrane
GO:0007165	signal transduction
GO:0007519	skeletal muscle tissue development
GO:0019221	cytokine-mediated signaling pathway
GO:0030036	actin cytoskeleton organization
GO:0030154	cell differentiation

Cellular Component

GO:0001725	stress fiber
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0005938	cell cortex
GO:0015629	actin cytoskeleton
GO:0016021	integral component of membrane
GO:0030018	Z disc
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000025278

View Gene Order

ENSBTAG00000022004

Not yet available

Pathways

NETPATH

NetPath_4

EGFR1 pathway

NetPath_11

TCR pathway

REACTOME

REACT_115831

ISG15 antiviral mechanism pathway

REACT_115676

Antiviral mechanism by IFN-stimulated genes pathway

REACT_75790

Cytokine Signaling in Immune system pathway

REACT_25229

Interferon Signaling pathway

REACT_6900

Immune System pathway

KEGG

hsa04010

MAPK signaling pathway pathway

hsa04510

Focal adhesion pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.476448 Hs.574321

RefSeq

NM_001164317 NM_001164318 NM_001164319 NM_001457 XM_005264981 XM_005264982

HUGO

OMIM

CCDS

CCDS2885 CCDS54599 CCDS54600 CCDS54601

HPRD

04543

IMGT

EMBL

GenPept

RNA Seq Atlas