Version 5.4
| Homo sapiens Gene: TAC3 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-41810.5 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | TAC3 | ||||||||||||||||||
| Gene Name | tachykinin 3 | ||||||||||||||||||
| Synonyms | HH10; NKB; NKNB; PRO1155; ZNEUROK1 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000166863 | ||||||||||||||||||
| Encoded Proteins |
tachykinin 3
tachykinin 3
tachykinin 3
tachykinin 3
tachykinin 3
tachykinin 3
tachykinin 3
tachykinin 3
tachykinin 3
tachykinin 3
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded protein is primarily expressed in the central and peripheral nervous system and functions as a neurotransmitter. This protein is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 12:57010000-57028883 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q13.3 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
G alpha (q) signalling events pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Tachykinin receptors bind tachykinins pathway
Peptide ligand-binding receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
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| KEGG | |||||||||||||||||||
| INOH |
GPCR signaling pathway
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| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | Q9UHF0 | ||||||||||||||||||
| TrEMBL | A0A024RB97 Q2UVB8 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 6866 | ||||||||||||||||||
| UniGene | Hs.9730 | ||||||||||||||||||
| RefSeq | NM_001178054 NM_013251 XM_006719577 XM_006719578 XM_006719579 XM_006719580 | ||||||||||||||||||
| HUGO | HGNC:11521 | ||||||||||||||||||
| OMIM | 162330 | ||||||||||||||||||
| CCDS | CCDS53803 CCDS8928 | ||||||||||||||||||
| HPRD | 08877 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AF186112 AF216586 AF537113 AF537114 AF537115 AF537116 AF537117 AF537118 AF537119 AF537120 AF537121 AM179832 AY358679 BC032145 CH471054 CR457193 | ||||||||||||||||||
| GenPept | AAF01430 AAF76980 AAH32145 AAQ10783 AAQ10784 AAQ10785 AAQ10786 AAQ10787 AAQ10788 AAQ10789 AAQ10790 AAQ10791 AAQ89042 CAG33474 CAJ47374 EAW96973 EAW96975 EAW96980 | ||||||||||||||||||
| RNA Seq Atlas | 6866 | ||||||||||||||||||