Version 5.4
Homo sapiens Gene: VCX3A
Summary
InnateDB Gene IDBG-41889.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VCX3A
Gene Name variable charge, X-linked 3A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000169059
Encoded Proteins
IDBP-41891
variable charge, X-linked 3A
IDBP-232380
variable charge, X-linked 3A
IDBP-807297
variable charge, X-linked 3A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 8 repeats of the 30-bp unit. [provided by RefSeq, Jul 2008] This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 10 repeats of the 30-bp unit. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:6533618-6535118
Strand Reverse strand
Band p22.31
Transcripts
ENST00000381089 ENSP00000370479
ENST00000398729 ENSP00000381713
ENST00000612369 ENSP00000478811
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007420 brain development
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q9NNX9
TrEMBL E7ESE9
UniProt Splice Variant
Entrez Gene 51481
UniGene Hs.278906
RefSeq NM_016379
HUGO HGNC:18159
OMIM 300229 300533
CCDS CCDS35199
HPRD
IMGT
EMBL AC108684 AF159128 AF167078 AJ243947
GenPept AAF28173 AAG41764 CAB56197
RNA Seq Atlas 51481

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca