Homo sapiens Gene: PDHB
Summary
InnateDB Gene IDBG-42225.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol PDHB
Gene Name pyruvate dehydrogenase (lipoamide) beta
Synonyms PDHBD; PDHE1-B; PHE1B;
Species Homo sapiens
Ensembl Gene ENSG00000168291
Encoded Proteins
pyruvate dehydrogenase (lipoamide) beta
pyruvate dehydrogenase (lipoamide) beta
pyruvate dehydrogenase (lipoamide) beta
pyruvate dehydrogenase (lipoamide) beta
pyruvate dehydrogenase (lipoamide) beta
Protein Structure
Entrez Gene
Summary The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and carbon dioxide, and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 beta subunit. Mutations in this gene are associated with pyruvate dehydrogenase E1-beta deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:58413357-58419584
Strand Reverse strand
Band p14.3
Transcripts
ENST00000302746 ENSP00000307241
ENST00000383714 ENSP00000373220
ENST00000469364 ENSP00000419580
ENST00000485460 ENSP00000417267
ENST00000479945
ENST00000474765 ENSP00000418448
ENST00000461692
ENST00000480626
ENST00000482894
ENST00000469827
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 42 [view]
Protein-Protein 42 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity
Biological Process
GO:0006086 acetyl-CoA biosynthetic process from pyruvate
GO:0006090 pyruvate metabolic process
GO:0006096 glycolysis
GO:0006099 tricarboxylic acid cycle
GO:0008152 metabolic process
GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0045254 pyruvate dehydrogenase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Regulation of pyruvate dehydrogenase (PDH) complex pathway
Pyruvate metabolism pathway
KEGG
Valine, leucine and isoleucine biosynthesis pathway
Glycolysis / Gluconeogenesis pathway
Pyruvate metabolism pathway
Butanoate metabolism pathway
Citrate cycle (TCA cycle) pathway
Metabolic pathways pathway
INOH
Pyruvate metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P11177
TrEMBL C9J634 F8WF02
UniProt Splice Variant
Entrez Gene 5162
UniGene Hs.161357 Hs.613823
RefSeq NM_000925 NM_001173468
HUGO 8808
OMIM 179060
CCDS CCDS2890 CCDS54602
HPRD 01530
IMGT
EMBL AC135507 AK293153 AK313022 AL117618 BC000439 BC001924 CH471055 CR541911 D90086 J03576 M19123 M34055 M34056 M34479 M54788 X57778
GenPept AAA36428 AAA60052 AAA60053 AAA60054 AAA60233 AAA88097 AAH00439 AAH01924 BAA14123 BAG35857 BAG56698 CAA40924 CAB56017 CAG46709 EAW65371
ImmGen PDHB (murine)
RNA Seq Atlas 5162