InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NPY2R

Summary

InnateDB Gene

IDBG-42275.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NPY2R

Gene Name

neuropeptide Y receptor Y2

Synonyms

NPY2-R

Species

Homo sapiens

Ensembl Gene

ENSG00000185149

Encoded Proteins

IDBP-42277

neuropeptide Y receptor Y2

IDBP-482721

neuropeptide Y receptor Y2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:155208629-155217078

Strand

Forward strand

Band

q32.1

Transcripts

ENST00000329476	ENSP00000332591
ENST00000506608	ENSP00000426366

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001601	peptide YY receptor activity
GO:0004872	receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004983	neuropeptide Y receptor activity
GO:0005246	calcium channel regulator activity
GO:0005515	protein binding

Biological Process

GO:0001662	behavioral fear response
GO:0002793	positive regulation of peptide secretion
GO:0003151	outflow tract morphogenesis
GO:0003214	cardiac left ventricle morphogenesis
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007218	neuropeptide signaling pathway
GO:0007263	nitric oxide mediated signal transduction
GO:0007626	locomotory behavior
GO:0030818	negative regulation of cAMP biosynthetic process
GO:0031645	negative regulation of neurological system process
GO:0033603	positive regulation of dopamine secretion
GO:0045785	positive regulation of cell adhesion
GO:0045987	positive regulation of smooth muscle contraction
GO:0046010	positive regulation of circadian sleep/wake cycle, non-REM sleep
GO:0046903	secretion
GO:0050805	negative regulation of synaptic transmission
GO:0051048	negative regulation of secretion
GO:0051930	regulation of sensory perception of pain
GO:0051967	negative regulation of synaptic transmission, glutamatergic
GO:0090394	negative regulation of excitatory postsynaptic membrane potential
GO:2000252	negative regulation of feeding behavior

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028004

View Gene Order

ENSBTAG00000016633

Not yet available

Pathways

NETPATH

REACTOME

REACT_19231

G alpha (i) signalling events pathway

REACT_14819

Peptide ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

P49146

TrEMBL

UniProt Splice Variant

Entrez Gene

4887

UniGene

Hs.37125

RefSeq

NM_000910 XM_005263033 XM_005263034

HUGO

HGNC:7957

OMIM

162642

CCDS

CCDS3791

HPRD

IMGT

EMBL

AC104407 AY236540 BC075052 BC075053 CH471056 U32500 U36269 U42389 U42766 U50146 U76254

GenPept

AAA93170 AAB04120 AAB07760 AAC50281 AAC51115 AAD00248 AAH75052 AAH75053 AAO92062 AAY40940 EAX04901

RNA Seq Atlas

4887