InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ABCG1

Summary

InnateDB Gene

IDBG-4231.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABCG1

Gene Name

ATP-binding cassette, sub-family G (WHITE), member 1

Synonyms

ABC8; WHITE1

Species

Homo sapiens

Ensembl Gene

ENSG00000160179

Encoded Proteins

IDBP-4233

ATP-binding cassette, sub-family G (WHITE), member 1

IDBP-4235

ATP-binding cassette, sub-family G (WHITE), member 1

IDBP-4237

ATP-binding cassette, sub-family G (WHITE), member 1

IDBP-232963

ATP-binding cassette, sub-family G (WHITE), member 1

IDBP-232965

ATP-binding cassette, sub-family G (WHITE), member 1

IDBP-232967

ATP-binding cassette, sub-family G (WHITE), member 1

IDBP-368052

ATP-binding cassette, sub-family G (WHITE), member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20395559

ABCG1 regulates innate immunity in a tissue-selective manner and Abcg1(-/-) mice have an enhanced pulmonary host defence response driven predominantly by hematopoietic cells.

InnateDB Annotation from Orthologs

Summary

PMID 20395559

[Mus musculus] Abcg1 regulates innate immunity in a tissue-selective manner and Abcg1(-/-) mice have an enhanced pulmonary host defense response driven predominantly by hematopoietic cells.

Entrez Gene

Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:42199689-42297244

Strand

Forward strand

Band

q22.3

Transcripts

ENST00000347800	ENSP00000291524
ENST00000361802	ENSP00000354995
ENST00000343687	ENSP00000339744
ENST00000398457	ENSP00000381475
ENST00000398449	ENSP00000381467
ENST00000398437	ENSP00000381464
ENST00000450121	ENSP00000414541
ENST00000462050
ENST00000472587
ENST00000467818
ENST00000496783

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0005543	phospholipid binding
GO:0005548	phospholipid transporter activity
GO:0015485	cholesterol binding
GO:0016887	ATPase activity
GO:0017127	cholesterol transporter activity
GO:0019534	toxin transporter activity
GO:0034041	sterol-transporting ATPase activity
GO:0034437	glycoprotein transporter activity
GO:0042803	protein homodimerization activity
GO:0043531	ADP binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006355	regulation of transcription, DNA-templated
GO:0006810	transport
GO:0008203	cholesterol metabolic process
GO:0009720	detection of hormone stimulus
GO:0010033	response to organic substance
GO:0010745	negative regulation of macrophage derived foam cell differentiation
GO:0010872	regulation of cholesterol esterification
GO:0010875	positive regulation of cholesterol efflux
GO:0010887	negative regulation of cholesterol storage
GO:0010888	negative regulation of lipid storage
GO:0030301	cholesterol transport
GO:0032367	intracellular cholesterol transport
GO:0033344	cholesterol efflux
GO:0033700	phospholipid efflux
GO:0033993	response to lipid
GO:0034374	low-density lipoprotein particle remodeling
GO:0034375	high-density lipoprotein particle remodeling
GO:0034436	glycoprotein transport
GO:0042157	lipoprotein metabolic process
GO:0042632	cholesterol homeostasis
GO:0042987	amyloid precursor protein catabolic process
GO:0043691	reverse cholesterol transport
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045542	positive regulation of cholesterol biosynthetic process
GO:0055085	transmembrane transport
GO:0055091	phospholipid homeostasis
GO:0055099	response to high density lipoprotein particle stimulus
GO:1901998	toxin transport

Cellular Component

GO:0000139	Golgi membrane
GO:0005739	mitochondrion
GO:0005768	endosome
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0055037	recycling endosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000024030

View Gene Order

ENSBTAG00000021272

Not yet available

Pathways

NETPATH

REACTOME

REACT_111158

ABCA transporters in lipid homeostasis pathway

REACT_15480

ABC-family proteins mediated transport pathway

REACT_13621

HDL-mediated lipid transport pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_6823

Lipoprotein metabolism pathway

REACT_111217

Metabolism pathway

REACT_602

Lipid digestion, mobilization, and transport pathway

KEGG

hsa02010

ABC transporters pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.124649 Hs.670265 Hs.714136

RefSeq

NM_004915 NM_016818 NM_207174 NM_207627 NM_207628 NM_207629

HUGO

OMIM

CCDS

CCDS13681 CCDS13682 CCDS13683 CCDS42937 CCDS42938

HPRD

04355

IMGT

EMBL

GenPept

RNA Seq Atlas