Homo sapiens Gene: FHIT | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-42471.7 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | FHIT | ||||||||||||||||||
Gene Name | fragile histidine triad | ||||||||||||||||||
Synonyms | AP3Aase; FRA3B | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000189283 | ||||||||||||||||||
Encoded Proteins |
fragile histidine triad gene
fragile histidine triad gene
fragile histidine triad gene
fragile histidine triad gene
fragile histidine triad gene
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009] This gene, a member of the histidine triad gene family, encodes a diadenosine 5\',5\'\'\'-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 3:59749310-61251459 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | p14.2 | ||||||||||||||||||
Transcripts | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME | |||||||||||||||||||
KEGG |
Non-small cell lung cancer pathway
Purine metabolism pathway
Small cell lung cancer pathway
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INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | P49789 | ||||||||||||||||||
TrEMBL | A0A024R366 E9PBZ0 Q194U8 Q1WAB3 Q71VB2 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 2272 | ||||||||||||||||||
UniGene | Hs.655995 | ||||||||||||||||||
RefSeq | XM_005264951 XM_006713027 NM_001166243 NM_002012 | ||||||||||||||||||
HUGO | HGNC:3701 | ||||||||||||||||||
OMIM | 601153 | ||||||||||||||||||
CCDS | CCDS2894 | ||||||||||||||||||
HPRD | 03096 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC093418 AC093556 AC096917 AC097357 AC098480 AC099536 AC099780 AC104164 AC132808 AC138071 AF020503 AF023460 AF152363 AF152364 AF152365 AK289824 AY625256 BC032336 CH471055 DQ120721 DQ416126 DQ666923 DQ865132 DQ865133 DQ865134 EF183457 EF183458 EF183459 EF183461 EF183462 EF183463 EF183464 EF186677 KJ534835 U46922 U76267 U76268 U76269 U76270 U76271 | ||||||||||||||||||
GenPept | AAA99013 AAB52539 AAB84098 AAB97515 AAH32336 AAT37530 AAZ23623 ABD93871 ABG02275 ABI15740 ABI15741 ABI15742 ABM65879 ABM66086 ABM66087 ABM66088 ABM66090 ABM66091 ABM66092 ABM66093 AHW56475 BAF82513 EAW65393 EAW65394 | ||||||||||||||||||
RNA Seq Atlas | 2272 | ||||||||||||||||||