Version 5.4
Homo sapiens Gene: ABCC4
Summary
InnateDB Gene IDBG-42534.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ABCC4
Gene Name ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Synonyms MOAT-B; MOATB; MRP4
Species Homo sapiens
Ensembl Gene ENSG00000125257
Encoded Proteins
IDBP-42536
ATP-binding cassette, sub-family C (CFTR/MRP), member 4
IDBP-595111
ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions. Alternative splicing results in multiple splice variants encoding different isoforms. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:95019829-95301433
Strand Reverse strand
Band q32.1
Transcripts
ENST00000376887 ENSP00000366084
ENST00000484109
ENST00000471041
ENST00000474158
ENST00000467685
ENST00000536256 ENSP00000442024
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 10 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity
GO:0016887 ATPase activity
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
Biological Process
GO:0002576 platelet degranulation
GO:0006200 ATP catabolic process
GO:0006810 transport
GO:0007596 blood coagulation
GO:0008150 biological_process
GO:0010033 response to organic substance
GO:0010243 response to organonitrogen compound
GO:0014070 response to organic cyclic compound
GO:0030168 platelet activation
GO:0042493 response to drug
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0055085 transmembrane transport
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0031088 platelet dense granule membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032849
View Gene Order
ENSBTAG00000032603
Not yet available
Pathways
NETPATH
REACTOME
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_15480
ABC-family proteins mediated transport pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_604
Hemostasis pathway
KEGG
hsa02010
ABC transporters pathway
hsa04976
Bile secretion pathway
INOH
PID NCI
Cross-References
SwissProt O15439
TrEMBL B7Z3Q7 Q8IUA3
UniProt Splice Variant
Entrez Gene 10257
UniGene Hs.508423 Hs.608649
RefSeq NM_001105515 NM_005845 XM_005254025
HUGO HGNC:55
OMIM 605250
CCDS CCDS9474
HPRD
IMGT
EMBL AF071202 AF541977 AK296247 AL139381 AL157818 AL356257 AL359750 AY081219 AY133679 AY133680 AY207008 BC041560 CH471085 U83660
GenPept AAB71757 AAC27076 AAH41560 AAL88745 AAN08629 AAN08630 AAN17334 AAO37649 BAH12293 CAC36037 CAI16589 CAI16722 EAX08949 EAX08950 EAX08951
RNA Seq Atlas 10257

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca