Homo sapiens Gene: CHST6

Summary
InnateDB Gene IDBG-42555.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol CHST6
Gene Name carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6
Synonyms MCDC1
Species Homo sapiens
Ensembl Gene ENSG00000183196
Encoded Proteins
IDBP-42557 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6
IDBP-42576 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6
Entrez Gene
Summary The protein encoded by this gene is an enzyme that catalyzes the transfer of a sulfate group to the GlcNAc residues of keratan. Keratan sulfate helps maintain corneal transparency. Defects in this gene are a cause of macular corneal dystrophy (MCD). [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16: 75510949-75529282
Strand Reverse strand
Band q23.1
Transcripts
ENST00000332272  ENSP00000328983
ENST00000390664  ENSP00000375079
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity
GO:0008146 sulfotransferase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006044 N-acetylglucosamine metabolic process
GO:0006790 sulfur compound metabolic process
GO:0018146 keratan sulfate biosynthetic process
GO:0030203 glycosaminoglycan metabolic process
GO:0042339 keratan sulfate metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016021 integral to membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000031952 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000040000 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
REACT_121120 Keratan sulfate biosynthesis
KEGG
hsa00533  Glycosaminoglycan biosynthesis - keratan sulfate
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9GZX3 
TrEMBL
UniProt Splice Variant
Entrez Gene 4166 
UniGene Hs.655622
RefSeq NM_021615 
HUGO 6938 
OMIM 605294
CCDS CCDS10918 
HPRD 05597
IMGT
EMBL AF219990 AF219991 AF280086 BC074834 BC074883 CH471114
GenPept AAG26325  AAG26327  AAG48244  AAH74834  AAH74883  EAW95640  EAW95641 
ImmGen CHST6 (murine) 
RNA Seq Atlas 4166