InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CNOT4

Summary

InnateDB Gene

IDBG-42604.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CNOT4

Gene Name

CCR4-NOT transcription complex, subunit 4

Synonyms

CLONE243; NOT4; NOT4H

Species

Homo sapiens

Ensembl Gene

ENSG00000080802

Encoded Proteins

IDBP-42608

CCR4-NOT transcription complex, subunit 4

IDBP-42610

CCR4-NOT transcription complex, subunit 4

IDBP-42612

CCR4-NOT transcription complex, subunit 4

IDBP-386564

CCR4-NOT transcription complex, subunit 4

IDBP-386565

CCR4-NOT transcription complex, subunit 4

IDBP-386567

CCR4-NOT transcription complex, subunit 4

IDBP-386569

CCR4-NOT transcription complex, subunit 4

IDBP-599931

CCR4-NOT transcription complex, subunit 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22159038

CNOT4 enhances JAK/STAT pathway-dependent gene expression by positively regulating IFN-gamma- and IL4-induced STAT-mediated gene responses.

InnateDB Annotation from Orthologs

Summary

PMID 22159038

[Mus musculus] Cnot4 enhances JAK/STAT pathway-dependent gene expression by positively regulating IFN-gamma- and IL4-induced STAT-mediated gene responses. (Demonstrated in human)

Entrez Gene

Summary

The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:135361795-135510127

Strand

Reverse strand

Band

q33

Transcripts

ENST00000361528	ENSP00000354673
ENST00000356162	ENSP00000348485
ENST00000315544	ENSP00000326731
ENST00000451834	ENSP00000388491
ENST00000423368	ENSP00000406777
ENST00000414802	ENSP00000416532
ENST00000428680	ENSP00000399108
ENST00000473470
ENST00000491203
ENST00000498534
ENST00000465721
ENST00000541284	ENSP00000445508

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	15 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0051865	protein autoubiquitination

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0030014	CCR4-NOT complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000038784

View Gene Order

ENSBTAG00000017919

Not yet available

Pathways

NETPATH

REACTOME

REACT_20514

Deadenylation of mRNA pathway

REACT_20639

Deadenylation-dependent mRNA decay pathway

REACT_71

Gene Expression pathway

KEGG

hsa03018

RNA degradation pathway

INOH

PID NCI

Cross-References

SwissProt

O95628

TrEMBL

A0A024R781

UniProt Splice Variant

Entrez Gene

4850

UniGene

Hs.490224

RefSeq

NM_001190847 NM_001008225 NM_001190848 NM_001190849 NM_001190850 NM_013316

HUGO

HGNC:7880

OMIM

604911

CCDS

CCDS55164 CCDS43650 CCDS47719 CCDS55165 CCDS55166 CCDS55167

HPRD

05369

IMGT

EMBL

AC074002 AC083871 AF091094 AF180475 AK074671 AK300365 AL389980 BC035590 CH471070 U71267 U71268

GenPept

AAC72963 AAD00179 AAD00180 AAF29829 AAH35590 BAC11125 BAH13270 CAB97536 EAW83850 EAW83851

RNA Seq Atlas

4850