InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ARHGAP9

Summary

InnateDB Gene

IDBG-42628.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGAP9

Gene Name

Rho GTPase activating protein 9

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000123329

Encoded Proteins

IDBP-242894

Rho GTPase activating protein 9

IDBP-242896

Rho GTPase activating protein 9

IDBP-378685

Rho GTPase activating protein 9

IDBP-378687

Rho GTPase activating protein 9

IDBP-596051

Rho GTPase activating protein 9

IDBP-808758

Rho GTPase activating protein 9

IDBP-590441

Rho GTPase activating protein 9

IDBP-593170

Rho GTPase activating protein 9

IDBP-592366

Rho GTPase activating protein 9

IDBP-583350

Rho GTPase activating protein 9

IDBP-595402

Rho GTPase activating protein 9

IDBP-589138

Rho GTPase activating protein 9

IDBP-587001

Rho GTPase activating protein 9

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity towards several Rho-family GTPases in vitro, converting them to an inactive GDP-bound state. It is implicated in regulating adhesion of hematopoietic cells to the extracellular matrix. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:57472255-57488814

Strand

Reverse strand

Band

q13.3

Transcripts

ENST00000393797	ENSP00000377386
ENST00000393791	ENSP00000377380
ENST00000424809	ENSP00000394307
ENST00000430041	ENSP00000397950
ENST00000552953
ENST00000550399	ENSP00000448404
ENST00000546200
ENST00000550288	ENSP00000473445
ENST00000550440
ENST00000550130	ENSP00000448423
ENST00000546704
ENST00000548139	ENSP00000449829
ENST00000548148
ENST00000550454
ENST00000547200
ENST00000552604	ENSP00000450256
ENST00000552420
ENST00000551574
ENST00000551452	ENSP00000446932
ENST00000552066	ENSP00000448424
ENST00000547216
ENST00000551000
ENST00000549602	ENSP00000450223
ENST00000552249	ENSP00000448358

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding

Biological Process

GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000040345

View Gene Order

ENSBTAG00000018403

Not yet available

Pathways

NETPATH

REACTOME

REACT_11051

Rho GTPase cycle pathway

REACT_11044

Signaling by Rho GTPases pathway

REACT_111102

Signal Transduction pathway

KEGG

INOH

PID NCI

rac1_reg_pathway

Regulation of RAC1 activity

rhoa_reg_pathway

Regulation of RhoA activity

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.437126 Hs.733177

RefSeq

NM_001080156 NM_001080157 NM_032496 XM_005269081 XM_005269082 XM_005269083 XM_006719560

HUGO

OMIM

CCDS

CCDS44928 CCDS44929 CCDS8941

HPRD

06449

IMGT

EMBL

GenPept

RNA Seq Atlas