InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KARS

Summary

InnateDB Gene

IDBG-42717.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KARS

Gene Name

lysyl-tRNA synthetase

Synonyms

CMTRIB; DFNB89; KARS1; KARS2; KRS

Species

Homo sapiens

Ensembl Gene

ENSG00000065427

Encoded Proteins

IDBP-42719

lysyl-tRNA synthetase

IDBP-42723

lysyl-tRNA synthetase

IDBP-748375

IDBP-749853

IDBP-749705

IDBP-745828

IDBP-747380

IDBP-748920

IDBP-751137

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:75627474-75648643

Strand

Reverse strand

Band

q23.1

Transcripts

ENST00000302445	ENSP00000303043
ENST00000319410	ENSP00000325448
ENST00000570215	ENSP00000458028
ENST00000566249	ENSP00000456786
ENST00000569298
ENST00000562875	ENSP00000456185
ENST00000566560
ENST00000565738
ENST00000564578	ENSP00000455818
ENST00000568682	ENSP00000462057
ENST00000568378	ENSP00000454512
ENST00000566772	ENSP00000455488

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 77 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	77 [view]
Protein-Protein	76 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000049	tRNA binding
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0004812	aminoacyl-tRNA ligase activity
GO:0004824	lysine-tRNA ligase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016597	amino acid binding
GO:0046872	metal ion binding

Biological Process

GO:0006418	tRNA aminoacylation for protein translation
GO:0006430	lysyl-tRNA aminoacylation
GO:0008033	tRNA processing
GO:0008219	cell death
GO:0010467	gene expression
GO:0015966	diadenosine tetraphosphate biosynthetic process
GO:0016032	viral process

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0015630	microtubule cytoskeleton
GO:0017101	aminoacyl-tRNA synthetase multienzyme complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000031948

View Gene Order

ENSBTAG00000015677

Not yet available

Pathways

NETPATH

REACTOME

REACT_15302

Mitochondrial tRNA aminoacylation pathway

REACT_15306

Cytosolic tRNA aminoacylation pathway

REACT_15482

tRNA Aminoacylation pathway

REACT_71

Gene Expression pathway

KEGG

hsa00970

Aminoacyl-tRNA biosynthesis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.3100

RefSeq

NM_001130089 NM_005548

HUGO

OMIM

CCDS

CCDS10923 CCDS45532

HPRD

03249

IMGT

EMBL

GenPept

RNA Seq Atlas